ArticleDiagnostic microbiology and infectious disease2016
Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis.
Article in Diagnostic microbiology and infectious disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Serum amyloid A and proadrenomedullin as early markers in critically ill children with sepsis.Clinical and experimental pediatrics · 2025Article
- Alterations in RNA Expression Profile FollowingInternational journal of molecular sciences · 2025Article
- Dynamic risk stratification and treatment optimization in sepsis: the role of NLPR.Frontiers in pharmacology · 2025Article
- Comparison of Trends of Procalcitonin and Neutrophil to Lymphocyte Ratio in Patients of Sepsis in Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Identifying biomarkers deciphering sepsis from trauma-induced sterile inflammation and trauma-induced sepsis.Frontiers in immunology · 2023Article
- A Minimal Parameter Set Facilitating Early Decision-making in the Diagnosis of Hemophagocytic Lymphohistiocytosis.Journal of clinical immunology · 2021Article
- Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020Review
- A 2020 review on the role of procalcitonin in different clinical settings: an update conducted with the tools of the Evidence Based Laboratory Medicine.Annals of translational medicine · 2020Review
- Differential protein expression in patients with urosepsis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Article
- Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis.Critical care medicine · 2018Article
- Observational
- Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis.Annals of intensive care · 2017Article
- Diagnosing sepsis - The role of laboratory medicine.Clinica chimica acta; international journal of clinical chemistry · 2016Review
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Among surgical intensive care unit (SICU) patients, it is difficult to distinguish bacterial sepsis from other causes of systemic inflammatory response syndrome (SIRS). Biomarkers have proven useful to identify the presence of bacterial infection. We enrolled a prospective cohort of 69 SICU patients with suspected sepsis and assayed the concentrations of 9 biomarkers (α-2 macroglobulin [A2M], C-reactive protein, ferritin, fibrinogen, haptoglobin, procalcitonin [PCT], serum amyloid A, serum amyloid P, and tissue plasminogen activator) at baseline, 24, 48, and 72hours. Forty-two patients (61%) had bacterial sepsis by chart review. A2M concentrations were significantly lower, and PCT concentrations were significantly higher in subjects with bacterial sepsis at 3 of 4 time points. Using optimal cutoff values, the combination of baseline A2M and 72-hour PCT achieved a negative predictive value of 75% (95% confidence interval, 54-96%). The combination of A2M and PCT discriminated bacterial sepsis from other SIRS among SICU patients with suspected sepsis.
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