ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2016
Pdgfra and Pdgfrb genetically interact during craniofacial development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 38 citations in OpenAlex.
- PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation.Nature communications · 2025Article
- Single-cell multiome characterizing intercellular communication and intracellular regulation of epithelium and mesenchymal during secondary palate development in mice.Computational and structural biotechnology journal · 2025Article
- Overview of Head Muscles with Special Emphasis on Extraocular Muscle Development.Advances in anatomy, embryology, and cell biology · 2023Article
- Embryonic Nicotine Exposure Disrupts Adult Social Behavior and Craniofacial Development in Zebrafish.Toxics · 2022Article
- Visualization of the Cartilage and Bone Elements in the Craniofacial Structures by Alcian Blue and Alizarin Red Staining.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Craniofacial and cardiac defects inFrontiers in cell and developmental biology · 2022Article
- Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development.Developmental biology · 2021Article
- AKT Signaling Modifies the Balance between Cell Proliferation and Migration in Neural Crest Cells from Patients Affected with Bosma Arhinia and Microphthalmia Syndrome.Biomedicines · 2021Article
- TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis.Nature communications · 2020Article
- Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Orofacial Muscles: Embryonic Development and Regeneration after Injury.Journal of dental research · 2020Review
- Article
- Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors.Frontiers in cell and developmental biology · 2020Review
- Molecular mechanisms underlying nuchal hump formation in dolphin cichlid, Cyrtocara moorii.Scientific reports · 2019Article
- The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Article
- Zebrafish models of orofacial clefts.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration.Development (Cambridge, England) · 2017Article
- Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche.Nature cell biology · 2017Article
- PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.Genes & development · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOne of the most prevalent congenital birth defects is cleft palate. The palatal skeleton is derived from the cranial neural crest and platelet-derived growth factors (Pdgf) are critical in palatogenesis. Of the two Pdgf receptors, pdgfra is required for neural crest migration and palatogenesis. However, the role pdgfrb plays in the neural crest, or whether pdgfra and pdgfrb interact during palatogenesis is unclear.
resultsWe find that pdgfrb is dispensable for craniofacial development in zebrafish. However, the palatal defect in pdgfra;pdgfrb double mutants is significantly more severe than in pdgfra single mutants. Data in mouse suggest this interaction is conserved and that neural crest requires both genes. In zebrafish, pdgfra and pdgfrb are both expressed by neural crest within the pharyngeal arches, and pharmacological analyses demonstrate Pdgf signaling is required at these times. While neither proliferation nor cell death appears affected, time-lapsed confocal analysis of pdgfra;pdgfrb mutants shows a failure of proper neural crest condensation during palatogenesis.
conclusionsWe provide data showing that pdgfra and pdgfrb interact during palatogenesis in both zebrafish and mouse. In zebrafish, this interaction affects proper condensation of maxillary neural crest cells, revealing a previously unknown interaction between Pdgfra and Pdgfrb during palate formation. Developmental Dynamics 245:641-652, 2016. © 2016 Wiley Periodicals, Inc.
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