ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2016
Hyperaldosteronism: Screening and Diagnostic Tests.
Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Role of Renin-Angiotensin-Aldosterone System and Cortisol in Endometriosis: A Preliminary Report.International journal of molecular sciences · 2022Article
- Imaging or Adrenal Vein Sampling Approach in Primary Aldosteronism? A Patient-Based Approach.Tomography (Ann Arbor, Mich.) · 2022Review
- Evaluation and implications of salt intake and excretion.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- A family with Liddle's syndrome caused by a new c.1721 deletion mutation in the epithelial sodium channel β-subunit.Experimental and therapeutic medicine · 2019Article
- Minimally Invasive Surgery-Based Multidisciplinary Clinical Management of Reninoma: A Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Secondary Arterial Hypertension: From Routine Clinical Practice to Evidence in Patients with Adrenal Tumor.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018Review
- Relationship between water and salt intake, osmolality, vasopressin, and aldosterone in the regulation of blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary aldosteronism (PA) is the most common secondary cause of hypertension, accounting for 10 % of hypertensives and 20 % of those with drug-resistant hypertension. Aldosterone excess is associated with the development of adverse cardiovascular, renal and metabolic effects that are partly independent of its effect on blood pressure. Guidelines recommended wider screening for PA in an effort to maximize detection of patients who may benefit from optimal, specific management. All patient groups with increased prevalence of PA, including hypertensive patients with type 2 diabetes mellitus and those with obstructive sleep apnea, should be carefully screened for PA. Screening with aldosterone-to-renin ratio (ARR) is the most practical and informative initial test. Subsequent confirmatory tests are: (1) oral salt loading; (2) saline infusion; (3) captopril challenge and (4) fludrocortisone suppression test. Confirmation of PA can avoid that patients with a false positive ARR would inappropriately undergo costly and harmful lateralization procedures. If confirmatory testing is positive, further investigations are directed toward determining the subtype of PA, as the treatment differs for each subtype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.