ArticleParasites & vectors2016
Schistosoma japonicum HSP60-derived peptide SJMHE1 suppresses delayed-type hypersensitivity in a murine model.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Glycogen Hydrogel Loaded withBiomolecules · 2026Article
- Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis.Psoriasis (Auckland, N.Z.) · 2025Article
- Helminth-derived molecules: Pathogenic and pharmacopeial roles.Journal of biomedical research · 2024Article
- Schistosoma antigens: A future clinical magic bullet for autoimmune diseases?Parasite (Paris, France) · 2024Review
- Article
- SJMHE1 protects against excessive iodine-induced pyroptosis in human thyroid follicular epithelial cells through a toll-like receptor 2-dependent pathway.International journal of medical sciences · 2022Article
- Helminth infection and helminth-derived products: A novel therapeutic option for non-alcoholic fatty liver disease.Frontiers in immunology · 2022Review
- Schistosoma japonicum peptide SJMHE1 inhibits acute and chronic colitis induced by dextran sulfate sodium in mice.Parasites & vectors · 2021Article
- Mining Helminths for Novel Therapeutics.Trends in molecular medicine · 2021Review
- Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections.Parasite immunology · 2021Review
- SJMHE1 Peptide fromJournal of inflammation research · 2021Article
- Helminth Induced Immunoregulation and Novel Therapeutic Avenue of Allergy.Journal of asthma and allergy · 2020Review
- Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice.Journal of cellular and molecular medicine · 2019Article
- Somatic extracts of Marshallagia marshalli downregulate the Th2 associated immune responses in ovalbumin-induced airway inflammation in BALB/c mice.Parasites & vectors · 2017Article
- Inhibition of cytokine response to TLR stimulation and alleviation of collagen-induced arthritis in mice by Schistosoma japonicum peptide SJMHE1.Journal of cellular and molecular medicine · 2017Article
- TLR Specific Immune Responses against Helminth Infections.Journal of parasitology research · 2017Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParasite-derived molecules with immunomodulatory properties, which have been optimised during host-parasite co-evolution, exhibit potential applications as novel immunotherapeutics. We have previously demonstrated that Schistosoma japonicum HSP60-derived peptide SJMHE1 induces CD4(+)CD25(+) regulatory T-cells (Tregs) and that adoptively transferred SJMHE1-induced CD4(+)CD25(+) Tregs inhibit delayed-type hypersensitivity (DTH) in mice. However, multiple concerns regarding this method render this treatment unsuitable. To gain further insights into the potential effects of SJMHE1, we used ovalbumin (OVA)-induced DTH and evaluated the effect of SJMHE1 on DTH mice.
methodsBALB/c mice were sensitised with OVA alone or combined with SJMHE1 and then challenged with OVA to induce DTH. We first analysed the potential effects of SJMHE1 by measuring DTH responses, T-cell responses, cytokine secretion, and Treg proportions. We then evaluated the expression levels of IL-10 and TGF-β1 in CD4(+)CD25(+) T-cells during DTH and Treg generation to identify the mechanism by which SJMHE1 suppresses DTH.
resultsSJMHE1 modulated the effector response against OVA-induced DTH and stimulated the production of the anti-inflammatory cytokines IL-10 and TGF-β1 in immunised mice through a mechanism involving CD4(+)CD25(+) Tregs. SJMHE1-induced CD4(+)CD25(+) Tregs expressed high levels of CTLA-4, IL-10, and TGF-β1, which substantially contributed to the suppressive activity during DTH. The administration of SJMHE1 to DTH in mice led to the expansion of CD4(+)CD25(+) Tregs from CD4(+)CD25(-) T-cells in the periphery, which inhibited DTH responses.
conclusionsOur study proves that the parasite-driven peptide suppresses DTH in mice, which may confer a new option for inflammation treatment.
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