Evidence map›Paper›PMID 26971179›Full record

ArticleDiagnostic microbiology and infectious disease2016

In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci.

Stephanie L Silva-Del Toro, Kerryl E Greenwood-Quaintance, Robin Patel

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Treatment ofAntibiotics (Basel, Switzerland) · 2023
    Review
  5. Review
  6. Linezolid Resistance inFrontiers in public health · 2021
    Article
  7. Review
  8. Article
  9. Review
  10. In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie L Silva-Del ToroDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Kerryl E Greenwood-QuaintanceDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Robin PatelDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: patel.robin@mayo.edu.

Funding

TRAINING IN TRANSLATIONAL RESEARCH: BENCH TO BEDSIDER25GM055252 · NIGMS · MAYO CLINIC ROCHESTER · PI LUJAN, LUIS, MAHER, LOUIS JAMES · 1996 to 2022
$8.3M
Post-baccalaureate Training in Biomedical ResearchR25GM075148 · NIGMS · MAYO CLINIC ROCHESTER · PI LUJAN, LUIS, MAHER, LOUIS JAMES · 2006 to 2024
$6.1M
NIGMS NIH HHS R25 GM055252NIGMS NIH HHS R25 GM075148NIGMS NIH HHS R25GM075148
6 · The paper itself

Abstract

The tedizolid MIC of 27 clinical isolates of linezolid-resistant staphylococci and enterococci was determined. Tedizolid MICs were ≥1μg/mL and were 4- to 32-fold lower than those of linezolid. Linezolid resistance mechanisms included G2576T 23S rRNA gene and rplC and rplD mutations.

Indexed as

Drug Resistance, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsEnterococcusHumansLinezolidMutationOrganophosphatesOxazolesRNA, Ribosomal, 23SStaphylococcusAnti-Bacterial AgentsLinezolidOrganophosphatesOxazolesRNA, Ribosomal, 23Stedizolid phosphateAntimicrobial resistanceLinezolid resistanceMultidrug resistanceTedizolid resistanceVancomycin resistant

Identifiers

PMID26971179
PMCPMC8067670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.