Evidence map›Paper›PMID 26970739›Full record

ReviewCancer causes & control : CCC2016

Breast cancer survival among young women: a review of the role of modifiable lifestyle factors.

Darren R Brenner, Nigel T Brockton, Joanne Kotsopoulos, Michelle Cotterchio, Beatrice A Boucher, Kerry S Courneya, Julia A Knight, Ivo A Olivotto, May Lynn Quan, Christine M Friedenreich

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.

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  10. Mortality of uveal melanoma in children and adolescents from 2004 to 2020.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Darren R BrennerDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 513, Holy Cross Centre, Box ACB, 2210-2nd St. SW, Calgary, AB, T2S 3C3, Canada. Darren.Brenner@albertahealthservices.ca.
Nigel T BrocktonDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 513, Holy Cross Centre, Box ACB, 2210-2nd St. SW, Calgary, AB, T2S 3C3, Canada.
Joanne KotsopoulosWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Michelle CotterchioDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Beatrice A BoucherDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
Kerry S CourneyaFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Julia A KnightDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Ivo A OlivottoDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
May Lynn QuanDepartment of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Room 513, Holy Cross Centre, Box ACB, 2210-2nd St. SW, Calgary, AB, T2S 3C3, Canada.
University of Calgary · CAUniversity of Toronto · CAAlberta Health Services · CAUniversity of Alberta · CAWomen's College Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Almost 7% of breast cancers are diagnosed among women age 40 years and younger in Western populations. Clinical outcomes among young women are worse. Early age-of-onset increases the risk of contralateral breast cancer, local and distant recurrence, and subsequent mortality. Breast cancers in young women (BCYW) are more likely to present with triple-negative (TNBC), TP53-positive, and HER-2 over-expressing tumors than among older women. However, despite these known differences in breast cancer outcomes and tumor subtypes, there is limited understanding of the basic biology, epidemiology, and optimal therapeutic strategies for BCYW. Several modifiable lifestyle factors associated with reduced risk of developing breast cancer have also been implicated in improved prognosis among breast cancer survivors of all ages. Given the treatment-related toxicities and the extended window for late effects, long-term lifestyle modifications potentially offer significant benefits to BCYW. In this review, we propose a model identifying three main areas of lifestyle factors (energy imbalance, inflammation, and dietary nutrient adequacy) that may influence survival in BCYW. In addition, we provide a summary of mechanisms of action and a synthesis of previous research on each of these topics.

Indexed as

Erb-b2 Receptor Tyrosine KinasesLife StyleBreast NeoplasmsDietFemaleHumansNeoplasm Recurrence, LocalPrognosisSurvivorsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesBreast cancerEpidemiologyLifestyleModifiable factorsSurvivalYoung onset

Identifiers

PMID26970739
PMCPMC4796361
OpenAlexW2296126623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.