ReviewCurrent topics in developmental biology2016
Self-Organization of Spatial Patterning in Human Embryonic Stem Cells.
Review in Current topics in developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Advances in micropatterning technology for mechanotransduction research.Mechanobiology in medicine · 2024Review
- Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- 16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids.Development (Cambridge, England) · 2023Article
- The role of BMP4 signaling in trophoblast emergence from pluripotency.Cellular and molecular life sciences : CMLS · 2022Review
- Mechanical regulation of early vertebrate embryogenesis.Nature reviews. Molecular cell biology · 2022Review
- Applications of Brain Organoids for Infectious Diseases.Journal of molecular biology · 2022Review
- TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling.Cell reports · 2022Article
- Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism.Stem cell reports · 2022Article
- Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems.Research (Washington, D.C.) · 2021Article
- lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation.Nature cell biology · 2020Article
- Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.iScience · 2020Article
- Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells.Frontiers in cell and developmental biology · 2020Article
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment.Nature biotechnology · 2019Article
- Opening the black box: Stem cell-based modeling of human post-implantation development.The Journal of cell biology · 2019Review
- In Vitro Microscale Models for Embryogenesis.Advanced biosystems · 2018Article
- The bioelectric code: An ancient computational medium for dynamic control of growth and form.Bio Systems · 2018Review
- The rise of three-dimensional human brain cultures.Nature · 2018Review
- Assisted reproductive technologies to prevent human mitochondrial disease transmission.Nature biotechnology · 2017Article
- Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases.Cell reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The developing embryo is a remarkable example of self-organization, where functional units are created in a complex spatiotemporal choreography. Recently, human embryonic stem cells (ESCs) have been used to recapitulate in vitro the self-organization programs that are executed in the embryo in vivo. This represents an unique opportunity to address self-organization in humans that is otherwise not addressable with current technologies. In this chapter, we review the recent literature on self-organization of human ESCs, with a particular focus on two examples: formation of embryonic germ layers and neural rosettes. Intriguingly, both activation and elimination of TGFβ signaling can initiate self-organization, albeit with different molecular underpinnings. We discuss the mechanisms underlying the formation of these structures in vitro and explore future challenges in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.