ReviewJournal of anatomy2016
Diffusible iodine-based contrast-enhanced computed tomography (diceCT): an emerging tool for rapid, high-resolution, 3-D imaging of metazoan soft tissues.
Review in Journal of anatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
223 citing papers in PubMed, 1 synthesis or guideline pooled it, 536 citations in OpenAlex.
- Novel imaging techniques to study postmortem human fetal anatomy: a systematic review on microfocus-CT and ultra-high-field MRI.European radiology · 2020Pooled it
- Integrative architecture and structural boundaries of the subdigital adhesive toe pads of Gekko gecko (Linnaeus, 1758) and guidelines for toe pad demarcation in other geckos.Journal of anatomy · 2026Article
- Proteomic study for the prediction ofHistochemistry and cell biology · 2026Article
- African wild dog (Lycaon pictus) masticatory apparatus and oral cavity morphology.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- An Optimized Freeze-Dry Multimodal Workflow for Sequential Micro-CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Innervation of the anal canal revisited through micro-CT imaging.Journal of anatomy · 2026Article
- A Novel Organizational Pattern of the Nasofrontal Complex inAnimals : an open access journal from MDPI · 2026Article
- Organ-Specific Responses to Plant Secondary Metabolites Reveal Mechanisms of Adaptation.Archives of insect biochemistry and physiology · 2026Article
- A 3D atlas of the trigeminal nerve and its relevance for comparative studies of the masticatory apparatus in rodents.Journal of anatomy · 2026Article
- Powerful or non-powerful? Revisiting hallucal grasping as a key evolutionary innovation in small arboreal mammals.iScience · 2026Article
- Quadrate orientation and joint reaction force underwent correlated evolution during suchian evolution.Journal of anatomy · 2026Article
- Bioimaging of sense organs and the central nervous system in extant fishes and reptiles in situ: A review.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- High-throughput phenomics of global ant biodiversity.Nature methods · 2026Article
- Anatomical Atlas and Three-Dimensional Musculoskeletal Model of the Flight Apparatus in the Southern Screamer (Anseriformes:Integrative organismal biology (Oxford, England) · 2026Article
- Primate Swallowing Is Powered by Both Rotation and Contraction of Suprahyoid Muscles.American journal of biological anthropology · 2026Article
- Morphology of the light-organ system and bioluminescent blinking in the ponyfish tribe Equulitini (Teleostei: Leiognathidae).PloS one · 2026Article
- Advances in multiscale myelin imaging: from classical histology to functional insights.Frontiers in cellular neuroscience · 2026Review
- Micro-computed tomography of termite gut anatomy: effects of staining regime on resolvability.PeerJ · 2026Article
- Imaging and Diagnostic Tools for Cetacean Mammary Gland Assessment: Challenges and Future Directions for Marine Mammal Pathology, Medicine and Research.Journal of mammary gland biology and neoplasia · 2025Review
- Optimizing diceCT protocols for post-mortem cetacean imaging: diffusible iodine enhancement of a rare narrow-ridged finless porpoise (Neophocaena asiaeorientalis) fetal specimen using clinical-grade computed tomography.BMC veterinary research · 2025Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 15 institutions in 5 countries.
Funding
Abstract
Morphologists have historically had to rely on destructive procedures to visualize the three-dimensional (3-D) anatomy of animals. More recently, however, non-destructive techniques have come to the forefront. These include X-ray computed tomography (CT), which has been used most commonly to examine the mineralized, hard-tissue anatomy of living and fossil metazoans. One relatively new and potentially transformative aspect of current CT-based research is the use of chemical agents to render visible, and differentiate between, soft-tissue structures in X-ray images. Specifically, iodine has emerged as one of the most widely used of these contrast agents among animal morphologists due to its ease of handling, cost effectiveness, and differential affinities for major types of soft tissues. The rapid adoption of iodine-based contrast agents has resulted in a proliferation of distinct specimen preparations and scanning parameter choices, as well as an increasing variety of imaging hardware and software preferences. Here we provide a critical review of the recent contributions to iodine-based, contrast-enhanced CT research to enable researchers just beginning to employ contrast enhancement to make sense of this complex new landscape of methodologies. We provide a detailed summary of recent case studies, assess factors that govern success at each step of the specimen storage, preparation, and imaging processes, and make recommendations for standardizing both techniques and reporting practices. Finally, we discuss potential cutting-edge applications of diffusible iodine-based contrast-enhanced computed tomography (diceCT) and the issues that must still be overcome to facilitate the broader adoption of diceCT going forward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.