ArticleBirth defects research. Part A, Clinical and molecular teratology2016
Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 48 citations in OpenAlex.
- Relationship of prenatal pesticide exposures with prenatal ultrasound and birth growth measures among offspring of women living with HIV.International journal of hygiene and environmental health · 2026Article
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- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Maternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.Frontiers in public health · 2024Article
- Determinants of neural tube defects among women who gave birth in hospitals in Eastern Ethiopia: evidence from a matched case control study.BMC women's health · 2023Article
- Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand.International journal of environmental research and public health · 2021Article
- Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters.Environmental science and pollution research international · 2021Article
- Associations between cumulative environmental quality and ten selected birth defects in Texas.Birth defects research · 2021Article
- Exploring the risk of hypospadias in children born from mothers living close to a vineyard.PloS one · 2021Article
- Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.Birth defects research · 2019Article
- Maternal arsenic exposure and nonsyndromic orofacial clefts.Birth defects research · 2018Article
- Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence.International journal of environmental research and public health · 2018Review
- Association of pesticide exposure with human congenital abnormalities.Toxicology and applied pharmacology · 2018Review
- Using Watershed Boundaries to Map Adverse Health Outcomes: Examples From Nebraska, USA.Environmental health insights · 2018Article
- Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis.Environmental health : a global access science source · 2017Article
- Estimated Maternal Pesticide Exposure from Drinking Water and Heart Defects in Offspring.International journal of environmental research and public health · 2017Article
- Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children-A National Survey.International journal of environmental research and public health · 2016Article
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Authors and funding
7 authors at 7 institutions in 1 country.
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Abstract
backgroundBirth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects.
methodsWe conducted a case-control study to estimate the associations between a residence-based metric of agricultural pesticide exposure and birth defects. We linked singleton live birth records for 2003 to 2005 from the North Carolina (NC) State Center for Health Statistics to data from the NC Birth Defects Monitoring Program. Included women had residence at delivery inside NC and infants with gestational ages from 20 to 44 weeks (n = 304,906). Pesticide exposure was assigned using a previously constructed metric, estimating total chemical exposure (pounds of active ingredient) based on crops within 500 meters of maternal residence, specific dates of pregnancy, and chemical application dates based on the planting/harvesting dates of each crop. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals for four categories of exposure (<10(th) , 10-50(th) , 50-90(th) , and >90(th) percentiles) compared with unexposed. Models were adjusted for maternal race, age at delivery, education, marital status, and smoking status.
resultsWe observed elevated ORs for congenital heart defects and certain structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems (e.g., OR [95% confidence interval] [highest exposure vs. unexposed] for tracheal esophageal fistula/esophageal atresia = 1.98 [0.69, 5.66], and OR for atrial septal defects: 1.70 [1.34, 2.14]).
conclusionOur results provide some evidence of associations between residential exposure to agricultural pesticides and several birth defects phenotypes. Birth Defects Research (Part A) 106:240-249, 2016. © 2016 Wiley Periodicals, Inc.
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