Trial reportCancer2016
Web-based collaborative care intervention to manage cancer-related symptoms in the palliative care setting.
Trial report in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 18 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 18 syntheses or guidelines pooled it.
- Effectiveness of and implementation requirements for telehealth in palliative care patients with advanced cancer: A systematic review and meta-analysis.Palliative medicine · 2026Pooled it
- Stepped-care models for cancer symptom management: a systematic review of efficacy and cost-effectiveness.Journal of the National Cancer Institute · 2026Pooled it
- Effect of applying digital health in palliative care for patients with advanced cancer: a meta-analysis and systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Guideline
- Home-based supportive care in advanced cancer: systematic review.BMJ supportive & palliative care · 2024Pooled it
- Interventions to improve outcomes for caregivers of patients with advanced cancer: a meta-analysis.Journal of the National Cancer Institute · 2023Pooled it
- Case management interventions in chronic disease reduce anxiety and depressive symptoms: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Effectiveness of internet-based support interventions on patients with breast cancer: a systematic review and narrative synthesis.BMJ open · 2022Pooled it
- Supportive Care Interventions for People With Cancer Assisted by Digital Technology: Systematic Review.Journal of medical Internet research · 2021Pooled it
- Telephone interventions for symptom management in adults with cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Comparing Specialty and Primary Palliative Care Interventions: Analysis of a Systematic Review.Journal of palliative medicine · 2020Pooled it
- Are the MORECare guidelines on reporting of attrition in palliative care research populations appropriate? A systematic review and meta-analysis of randomised controlled trials.BMC palliative care · 2020Pooled it
- Association between dyadic interventions and outcomes in cancer patients: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Is care really shared? A systematic review of collaborative care (shared care) interventions for adult cancer patients with depression.BMC health services research · 2019Pooled it
- Electronic Systems for Patients to Report and Manage Side Effects of Cancer Treatment: Systematic Review.Journal of medical Internet research · 2019Pooled it
- Blended Interventions to Change Behavior in Patients With Chronic Somatic Disorders: Systematic Review.Journal of medical Internet research · 2017Pooled it
- Psychosocial interventions for fatigue during cancer treatment with palliative intent.The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- A phase II pilot randomized controlled trial of an integrated stepped collaborative care intervention for patients awaiting kidney transplantation (CARES-transplant).Journal of behavioral medicine · 2025Trial
- Advancing Care Team Adoption of Electronic Health Record Systems for Cancer Symptom Management: Findings From a Hybrid Type II, Cluster-Randomized, Stepped-Wedge Trial.JCO oncology practice · 2025Trial
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundThe aim of this study was to examine the efficacy of a collaborative care intervention in reducing depression, pain, and fatigue and improve quality of life.
methodsA total of 261 patients with advanced cancer and 179 family caregivers were randomized to a web-based collaborative care intervention or enhanced usual care. The intervention included the following: 1) a web site with written and audiovisual self-management strategies, a bulletin board, and other resources; 2) visits with a care coordinator during a physician's appointment every 2 months; and 3) telephone follow-up every 2 weeks. Primary patient outcomes included measures of depression, pain, fatigue, and health-related quality of life. Secondary outcomes included Interleukin (IL)-1α, IL-1β, IL-6, and IL-8 levels, Natural Killer (NK) cell numbers, and caregiver stress and depression.
resultsAt the baseline, 51% of the patients reported 1 or more symptoms in the clinical range. For patients who presented with clinical levels of symptoms and were randomized to the intervention, reductions in depression (Cohen's d = 0.71), pain (Cohen's d = 0.62), and fatigue (Cohen's d = 0.26) and improvements in quality of life (Cohen's d = 0.99) were observed when compared to those in the enhanced usual car arm at 6 months. Reductions in IL-6 (φ = 0.18), IL-1β (φ = 0.35), IL-1α (φ = 0.19), and IL-8 (φ = 0.15) and increases in NK cell numbers (φ = 0.23) were observed in comparison with enhanced usual care arm at 6 months. Reductions in caregiver stress (Cohen's d = 0.75) and depression (Cohen's d = 0.37) were observed at 6 months for caregivers whose loved ones were randomized to the intervention arm.
conclusionsThe integration of screening and symptom management into cancer care is recommended.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.