ReviewAllergy2016
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015.
Open access · bronzeAbstract readReview
In one paragraph
Review in Allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
12.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL.BMJ open respiratory research · 2019Pooled it
- Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis?Medicina (Kaunas, Lithuania) · 2020Trial
- Birch Rust Spore Exposure and Upper Airway Symptom Dynamics in a Subarctic Region: Indications for a Novel Seasonal Allergen.Clinical and translational allergy · 2026Article
- Metabolomic Approaches to Lung Function in Pediatric Asthma: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Allergen-specific IgE sensitization spectrum in 4,166 children with allergic diseases at a county-level hospital in eastern China: a retrospective cross-sectional study.Frontiers in allergy · 2026Article
- The Overlap of Allergic Disorders and Upper Gastrointestinal Symptoms: Beyond Eosinophilic Esophagitis.Nutrients · 2025Observational
- [Characteristics of allergen component in dust mite-induced allergic rhinitis patients].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- Allergen Sensitization in Children in Weifang, China: Differences Between Monosensitization and Polysensitization.Journal of asthma and allergy · 2023Article
- Article
- Whole-genome sequencing and gene network modules predict gemcitabine/carboplatin-induced myelosuppression in non-small cell lung cancer patients.NPJ systems biology and applications · 2020Article
- Environmental and Endogenous Acids Can Trigger Allergic-Type Airway Reactions.International journal of environmental research and public health · 2020Review
- Omics for the future in asthma.Seminars in immunopathology · 2020Review
- Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide.The British journal of dermatology · 2019Review
- Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children.The World Allergy Organization journal · 2019Article
- Precision Medicine in Rhinosinusitis.Current allergy and asthma reports · 2019Review
- Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma.Clinical and translational allergy · 2019Review
- Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project.Environmental health perspectives · 2018Article
- The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL.Allergy · 2018Article
- POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project.Clinical and translational allergy · 2018Review
- Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007-2012.Clinical and translational allergy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
99 authors at 20 institutions in 15 countries.
J BousquetUniversity Hospital, Montpellier, France. jean.bousquet@orange.fr.
J M AntoCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
M AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
C AuffrayEuropean Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
T KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
I MomasDepartment of Public Health and Health Products, Paris Descartes University-Sorbonne Paris Cité, Paris, France.
D S PostmaDepartment of Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
R ValentaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
M WickmanSachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
A Cambon-ThomsenUMR Inserm U1027 and Université de Toulouse III Paul Sabatier, Toulouse, France.
T HaahtelaSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
B N LambrechtVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
K C Lodrup CarlsenDepartment of Paediatrics, Faculty of Medicine, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.
G H KoppelmanDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
J SunyerCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
T ZuberbierSecretary General of the Global Allergy and Asthma European Network (GA2LEN), Allergy-Centre-Charité at the Department of Dermatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
I Annesi-MaesanoEPAR U707 INSERM, EPAR UMR-S UPMC, Paris VI, Paris, France.
A ArnoOnmedic Networks, Barcelona, Spain.
C Bindslev-JensenDepartment of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
G De CarloEFA European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium.
F ForastiereDepartment of Epidemiology, Regional Health Service Lazio Region, Rome, Italy.
J HeinrichInstitute of Epidemiology I, German Research Centre for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.
M L KowalskiDepartment of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland.
D MaierBiomax Informatics AG, Munich, Germany.
E MelénDepartment of Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
S PalkonenEFA European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium.
H A SmitJulius Center of Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
M StandlInstitute of Epidemiology I, German Research Centre for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.
J WrightBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
A AsarnojClinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
M BenetCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
N BallardiniSachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
J Garcia-AymerichCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
U GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
S GuerraCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
C HohmanInstitute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin, Berlin, Germany.
I KullSachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
C LupinekDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
M PinartCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
I SkrindoDepartment of Paediatrics, Faculty of Medicine, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.
M WestmanDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
D SmaggheInserm Transfert, Paris, France.
C AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
R AlbangBiomax Informatics AG, Munich, Germany.
V AnastasovaUMR Inserm U1027 and Université de Toulouse III Paul Sabatier, Toulouse, France.
N AndersonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
C BachertENT Department, Ghent University Hospital, Gent, Belgium.
S BallereauEuropean Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
F BallesterEnvironment and Health Area, Centre for Public Health Research (CSISP), CIBERESP, Department of Nursing, University of Valencia, Valencia, Spain.
X BasaganaCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
A BedbrookMACVIA-LR, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon, European Innovation Partnership on Active and Healthy Ageing Reference Site, France.
A BergstromInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
A von BergResearch Institute, Department of Pediatrics, Marien-Hospital, Wesel, Germany.
B BrunekreefJulius Center of Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
E BurteINSERM, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, UVSQ, Université Versailles St-Quentin-en-Yvelines, Paris, France.
K H CarlsenDepartment of Paediatrics, Oslo University Hospital, University of Oslo, Oslo, Norway.
L ChatziDepartment of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
J M CoquetVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
M CurinDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
P DemolyDepartment of Respiratory Diseases, Montpellier University Hospital, France.
E EllerDepartment of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
M P FantiniDepartment of Medicine and Public Health, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
B GerhardBiomax Informatics AG, Munich, Germany.
H HammadVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
L von HertzenSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
V HovlandDepartment of Paediatrics, Oslo University Hospital, University of Oslo, Oslo, Norway.
B JacqueminCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
J JustAllergology Department, Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand-Trousseau (APHP), Sorbonne Universités, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
T KellerInstitute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin, Berlin, Germany.
M KerkhofDepartment of Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
R KissDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
M KogevinasCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
S KoletzkoDivision of Paediatric Gastroenterology and Hepatology, Ludwig Maximilians University of Munich, Munich, Germany.
S LauDepartment for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
I LehmannDepartment of Environmental Immunology/Core Facility Studies, Helmholtz Centre for Environmental Research, UFZ, Leipzig, Germany.
N LemonnierEuropean Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
R McEachanBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
M MäkeläSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
J MestresChemotargets SL and Chemogenomics Laboratory, GRIB Unit, IMIM-Hospital del Mar and University Pompeu Fabra, Barcelona, Catalonia, Spain.
E MininaBiomax Informatics AG, Munich, Germany.
P MowinckelDepartment of Paediatrics, Oslo University Hospital, University of Oslo, Oslo, Norway.
R NadifINSERM, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, UVSQ, Université Versailles St-Quentin-en-Yvelines, Paris, France.
M NawijnDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
S OddieBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
J PelletEuropean Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
I PinDépartement de Pédiatrie, CHU de Grenoble, Grenoble Cedex 9, France.
D PortaDepartment of Epidemiology, Regional Health Service Lazio Region, Rome, Italy.
F RancièreDepartment of Public Health and Health Products, Paris Descartes University-Sorbonne Paris Cité, Paris, France.
A Rial-SebbagUMR Inserm U1027 and Université de Toulouse III Paul Sabatier, Toulouse, France.
Y SaeysVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
M J SchuijsVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
V SirouxInserm, U823, Grenoble, France.
C G TischerInstitute of Epidemiology I, German Research Centre for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.
M TorrentCentre for Research in Environmental Epidemiology (CREAL), ISGLoBAL, Barcelona, Spain.
R VarrasoINSERM, VIMA: Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, UVSQ, Université Versailles St-Quentin-en-Yvelines, Paris, France.
J De VochtEFA European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium.
K WengerBiomax Informatics AG, Munich, Germany.
S WieserDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
C XuDepartment of Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Inserm · FRUniversity Medical Center Groningen · NLBiomax Informatics (Germany) · DECenter for Research in Environmental Epidemiology · ESGhent University · BEMedical University of Vienna · ATOslo University Hospital · NOUniversitat Pompeu Fabra · ESCharité - Universitätsmedizin Berlin · DEKarolinska Institutet · SEUniversité Claude Bernard Lyon 1 · FRBradford Royal Infirmary · GBEuropean Federation of Allergy and Airways Diseases Patients Associations · BEHelmholtz Zentrum München · DEHelsinki University Hospital · FIUniversité Toulouse III - Paul Sabatier · FRUtrecht University · NLAgenzia Regionale Parchi · ITDélégation Paris 5 · FRKarolinska University Hospital · SE
Funding
No grant is acknowledged in the PubMed record.
Abstract
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
Indexed as
Disease ManagementEuropean UnionHealth PolicyHumansHypersensitivityImmunizationImmunoglobulin EInventionsPrecision MedicinePrognosisSystems BiologyWorld Health OrganizationImmunoglobulin EasthmaIgEmultimorbiditypolysensitizationrhinitis
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