ArticleAmerican journal of hypertension2016
Higher Blood Pressure Partially Links Greater Adiposity to Reduced Brain White Matter Integrity.
Article in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Alterations in whole-brain white matter structural network among females with abdominal obesity by appetite subtypes.Frontiers in nutrition · 2026Article
- Fitness and exercise effects on brain age: A randomized clinical trial.Journal of sport and health science · 2025Article
- Reduced DTI-ALPS in H-type hypertension: insights into perivascular space function.Frontiers in neurology · 2025Article
- Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study.Journal of neuroscience research · 2023Article
- Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease.Human brain mapping · 2023Article
- Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes.Reviews in endocrine & metabolic disorders · 2022Review
- Phenotype discovery from population brain imaging.Medical image analysis · 2021Article
- Higher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2021Review
- The prospective relationship between prehypertension, race, and whole-brain white matter microstructure.Journal of human hypertension · 2020Article
- Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies.Neurobiology of aging · 2019Review
- Aging and Hypertension - Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging.Frontiers in aging neuroscience · 2019Article
- Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals.AJNR. American journal of neuroradiology · 2018Article
- White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging.Metabolism: clinical and experimental · 2018Review
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish.Obesity (Silver Spring, Md.) · 2017Article
- Reduced fractional anisotropy in patients with major depressive disorder and associations with vascular stiffness.NeuroImage. Clinical · 2017Article
Corrections and comments
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4 authors.
Funding
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Abstract
backgroundAdiposity and elevated blood pressure (BP) are associated with brain structure abnormalities, but whether these effects are independent is unknown. We tested whether associations between adiposity and white matter integrity were explained by elevated BP.
methodsA sample of 209 middle-aged adults underwent diffusion tensor imaging to quantify indirect metrics of white matter structural integrity. These included putative markers of global white matter integrity (fractional anisotropy (FA)), axonal integrity (axial diffusivity), and myelin integrity (radial diffusivity). Participants were either normotensive or prehypertensive.
resultsAfter adjusting for age and sex, regression analyses showed that waist circumference was associated with FA (β = -0.15, P < 0.05) and axial diffusivity (β = -0.24, P < 0.001), and mean arterial pressure (MAP) was associated with FA (β = -0.21, P < 0.05). Direct and indirect effect analyses showed that waist circumference was indirectly associated with whole brain FA through MAP (β = -0.06), and directly related to whole brain axial diffusivity, independent of MAP (β = -0.24). Examination of specific white matter tracts yielded similar results; waist circumference was indirectly related to FA through MAP and radial diffusivity, and directly related to axial diffusivity, independent of MAP. Supplemental analyses using body mass index, systolic BP, and diastolic BP also yielded similar results.
conclusionThese findings suggest at least 2 mechanisms explain the adiposity and white matter association: one pathway through elevated BP impacting global white matter integrity and reducing integrity of the myelin sheath, and at least one other adiposity-specific pathway decreasing axonal integrity.
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