Trial reportContemporary clinical trials2016
A randomized phase II dose-response exercise trial among colon cancer survivors: Purpose, study design, methods, and recruitment results.
Trial report in Contemporary clinical trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The usage of population and disease registries as pre-screening tools for clinical trials, a systematic review.Systematic reviews · 2024Pooled it
- Behaviour change techniques used in lifestyle interventions that aim to reduce cancer-related fatigue in cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2023Pooled it
- Resistance training in breast cancer patients undergoing primary treatment: a systematic review and meta-regression of exercise dosage.Breast cancer (Tokyo, Japan) · 2021Pooled it
- Physical activity interventions for disease-related physical and mental health during and following treatment in people with non-advanced colorectal cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Evaluating recruitment, retention, and adherence patterns in the GET FIT fall prevention exercise trial in older, postmenopausal cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- The many faces of recruitment in a randomized controlled trial.Contemporary clinical trials · 2021Trial
- A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.Psycho-oncology · 2018Trial
- Dose-response Effects of Aerobic Exercise Among Colon Cancer Survivors: A Randomized Phase II Trial.Clinical colorectal cancer · 2018Trial
- Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer.PloS one · 2018Trial
- Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.British journal of cancer · 2017Trial
- A Systematic Review and Meta-Analysis of Physical Activity Interventions in Colorectal Cancer Survivors: An Evidence Evaluation Attempt Across Racial/Ethnic Groups.Healthcare (Basel, Switzerland) · 2025Review
- A randomized trial of aerobic exercise in colorectal cancer: Rationale, design, recruitment, and exercise adherence results.Contemporary clinical trials · 2024Article
- The dose-response effect of aerobic exercise on inflammation in colon cancer survivors.Frontiers in oncology · 2023Article
- Feasibility of a 12-Month Exercise Intervention in Postsurgical Colorectal Cancer Patients.Translational sports medicine · 2023Article
- Exercise and colorectal cancer: prevention and molecular mechanisms.Cancer cell international · 2022Review
- Variability and limitations in home-based exercise program descriptions in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Exercise as a prescription for patients with various diseases.Journal of sport and health science · 2019Review
- Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases.Cancer metastasis reviews · 2019Review
- The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial.Contemporary clinical trials communications · 2018Article
- Dose-response effects of exercise on insulin among colon cancer survivors.Endocrine-related cancer · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundObservational studies indicate that higher volumes of physical activity are associated with improved disease outcomes among colon cancer survivors. The aim of this report is to describe the purpose, study design, methods, and recruitment results of the courage trial, a National Cancer Institute (NCI) sponsored, phase II, randomized, dose-response exercise trial among colon cancer survivors. METHODS/
resultsThe primary objective of the courage trial is to quantify the feasibility, safety, and physiologic effects of low-dose (150 min·week(-1)) and high-dose (300 min·week(-1)) moderate-intensity aerobic exercise compared to usual-care control group over six months. The exercise groups are provided with in-home treadmills and heart rate monitors. Between January and July 2015, 1433 letters were mailed using a population-based state cancer registry; 126 colon cancer survivors inquired about participation, and 39 were randomized onto the study protocol. Age was associated with inquiry about study participation (P<0.001) and randomization onto the study protocol (P<0.001). No other demographic, clinical, or geographic characteristics were associated with study inquiry or randomization. The final trial participant was randomized in August 2015. Six month endpoint data collection was completed in February 2016. DISCUSSION: The recruitment of colon cancer survivors into an exercise trial is feasible. The findings from this trial will inform key design aspects for future phase 2 and phase 3 randomized controlled trials to examine the efficacy of exercise to improve clinical outcomes among colon cancer survivors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.