Evidence map›Paper›PMID 26970128›Full record

ReviewSeminars in oncology2016

The microbiome and its potential as a cancer preventive intervention.

Scott J Bultman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Adherence to Mediterranean Diet and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it
  3. The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Pooled it
  4. Pooled it
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  18. Current advances in microbial-based cancer therapies.Medical oncology (Northwood, London, England) · 2023
    Review
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  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Scott J BultmanDepartment of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address: Scott_Bultman@med.unc.edu.
UNC Lineberger Comprehensive Cancer Center

Funding

DEVELOPMENT OF HUMAN INTESTINAL SIMULACRAR01DK109559 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L., BULTMAN, SCOTT J · 2015 to 2019
$5.2M
Dietary Fiber, Gut Microflora, & Epigenetic Events that Prevent Colorectal CancerR01CA125237 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULTMAN, SCOTT J · 2007 to 2011
$1.4M
NCI NIH HHS R01 CA125237NIDDK NIH HHS R01 DK109559
6 · The paper itself

Abstract

It is becoming increasingly clear that microbiota inhabiting our bodies influence cancer predisposition and etiology. In addition to pathogens with oncogenic properties, commensal and symbiotic microbiota have tumor-suppressive properties. Diet and other environmental factors can modulate the abundance of certain members of microbial communities within the gastrointestinal tract and at other anatomical sites. Furthermore, some dietary factors are metabolized by commensal/symbiotic gut microbiota into bioactive food components believed to prevent cancer. For example, dietary fiber undergoes bacterial fermentation in the colon to yield butyrate, which is a short-chain fatty acid and histone deacetylase (HDAC) inhibitor that suppresses the viability and growth of colorectal cancer cell lines. A recent study using gnotobiotic mouse models demonstrates that fiber can protect against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner that involves the Warburg effect. This and other examples suggest that some of the inter-individual variation observed in epidemiology and intervention studies that have investigated associations between diet and cancer risk might be explained by differences in microbiota among the participants. Data from basic research studies also support the idea that probiotics and prebiotics could be plausible chemoprevention strategies that may be utilized to a greater extent in the future.

Indexed as

AnimalsButyratesColorectal NeoplasmsDietary FiberGastrointestinal MicrobiomeHumansMicrobial InteractionsPrebioticsProbioticsButyratesDietary FiberPrebioticsButyrateGut microbiomeHDAC inhibitor

Identifiers

PMID26970128
PMCPMC4789109
OpenAlexW1679213281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.