ReviewMolecular reproduction and development2016
The molecular complexity of fertilization: Introducing the concept of a fertilization synapse.
Review in Molecular reproduction and development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Characterization ofbioRxiv : the preprint server for biology · 2026Article
- Membrane Fusions During Mammalian Fertilization.Advances in experimental medicine and biology · 2026Review
- Sperm activation for fertilization requires robust activity of the TAT-5 lipid flippase.Developmental biology · 2025Article
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- The Caenorhabditis elegans spe-21 gene that encodes a palmitoyltransferase is necessary for spermiogenesis.Developmental biology · 2025Article
- Article
- The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.Current biology : CB · 2023Article
- CRISPR/Cas9 Mediated Fluorescent Tagging ofBiomolecules · 2023Article
- Where are all the egg genes?Frontiers in cell and developmental biology · 2023Review
- Eukaryotic fertilization and gamete fusion at a glance.Journal of cell science · 2022Article
- DMP8 and 9 regulate HAP2/GCS1 trafficking for the timely acquisition of sperm fusion competence.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly.Science advances · 2022Article
- Editorial: Fertilization in the spotlight: Dynamics and mechanisms of sperm-egg interaction.Frontiers in cell and developmental biology · 2022Article
- Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.G3 (Bethesda, Md.) · 2021Article
- The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- The molecular underpinnings of fertility: Genetic approaches inAdvanced genetics (Hoboken, N.J.) · 2021Article
- Fusexins, HAP2/GCS1 and Evolution of Gamete Fusion.Frontiers in cell and developmental biology · 2021Review
- Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Sydney Brenner: The birth of a model organism and the worm's connection to reproductive biology.Molecular reproduction and development · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The details of sperm-egg interactions remain a relative mystery despite many decades of research. As new molecular complexities are being discovered, we need to revise the framework in which we think about fertilization. As such, we propose that fertilization involves the formation of a synapse between the sperm and egg. A cellular synapse is a structure that mediates cell adhesion, signaling, and secretion through specialized zones of interaction and polarity. In this review, we draw parallels between the immune synapse and fertilization, and argue that we should consider sperm-egg recognition, binding, and fusion in the context of a "fertilization synapse." Mol. Reprod. Dev. 83: 376-386, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.