Evidence map›Paper›PMID 26969978›Full record

ReviewCurrent topics in developmental biology2016

Concepts of Cell Lineage in Mammalian Embryos.

Virginia E Papaioannou

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Tracking of lineage massLab on a chip · 2024
    Article
  2. Article
  3. Article
  4. Illumination of neural development byCell regeneration (London, England) · 2018
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Virginia E PapaioannouDepartment of Genetics and Development, Columbia University Medical Center, New York, USA. Electronic address: vep1@cumc.columbia.edu.

Funding

Role of T-box genes in mouse developmentR37HD033082 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PAPAIOANNOU, VIRGINIA E. · 2007 to 2016
$4.1M
NICHD NIH HHS R37 HD033082NICHD NIH HHS R37HD033082
6 · The paper itself

Abstract

Cell lineage is the framework for understanding cellular diversity, stability of differentiation, and its relationship to pluripotency. The special condition of in utero development in mammals has presented challenges to developmental biologists in tracing cell lineages but modern imaging and cell marking techniques have allowed the gradual elucidation of lineage relationships. Early experimental embryology approaches had limited resolution and relied of suboptimal cell markers and considerable disturbance to the embryos. Transgenic technology introduced genetic markers, particularly fluorescent proteins that, combined with sophisticated imaging modalities, greatly increase resolution and allow clonal analysis within lineages. The concept of cell lineage has also undergone evolution as it became possible to trace the lineage of cells based not only on their physical location or attributes but also on their gene expression pattern, thus opening up mechanistic lines of investigation into the determinants of cell lineage.

Indexed as

Cell DifferentiationCell LineageGene Expression Regulation, DevelopmentalAnimalsEmbryo, MammalianHumansMammalsClonal analysisGene expression lineage tracingMammalian cell lineageMouse embryo

Identifiers

PMID26969978
PMCPMC4793410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.