Evidence map›Paper›PMID 26969973›Full record

ReviewCurrent topics in developmental biology2016

The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.

Marek Mlodzik

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 75 citations in OpenAlex.

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  3. (Journal of medicinal chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Marek MlodzikDepartment of Developmental and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: marek.mlodzik@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

Retinal Patterning During Eye DevelopmentR01EY013256 · NEI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Marek Mlodzik · 2001 to 2026
$10.0M
Planar Cell Polarity regulation by transmembrane proteinsR01GM102811 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MLODZIK, MAREK · 2012 to 2017
$2.1M
Regulation of Wnt Pathway SpecificityR01HD066319 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AARONSON, STUART A, MLODZIK, MAREK · 2012 to 2016
$2.0M
Ubiquitin-like protein modifications in planar cell polarityR01GM104241 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MLODZIK, MAREK · 2014 to 2017
$1.3M
Dsh/Dvl Phosphorylation and Signaling OutcomeR21HD061799 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MLODZIK, MAREK · 2009 to 2010
$466k
NEI NIH HHS R01 EY013256NICHD NIH HHS R01 HD066319NICHD NIH HHS R21 HD061799NIGMS NIH HHS R01 GM102811NIGMS NIH HHS R01 GM104241
6 · The paper itself

Abstract

Dishevelled (Dsh) is a key component of Wnt-signaling pathways and possibly also has other functional requirements. Dsh appears to be a key factor to interpret Wnt signals coming via the Wnt-receptor family, the Frizzled proteins, from the plasma membrane and route them into the correct intracellular pathways. However, how Dsh is regulated to relay signal flow to specific and distinct cellular responses upon interaction with the same Wnt-receptor family remains very poorly understood.

Indexed as

Wnt Signaling PathwayAnimalsCytoplasmDishevelled ProteinsEndocytosisHumansSignal TransductionDishevelled ProteinsDishevelledFrizzledPlanar cell polaritySignaling specificityWnt signaling

Identifiers

PMID26969973
PMCPMC4939608
OpenAlexW2229568458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.