ArticleSocial cognitive and affective neuroscience2016
Opposing effects of negative emotion on amygdalar and hippocampal memory for items and associations.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of negative aesthetic evaluations in visual art: a neuroimaging meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2025Pooled it
- Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Trial
- Emotional salience of the image component facilitates recall of the text of cigarette warning labels.European journal of public health · 2019Trial
- Effect of emotion on hippocampal-dependent associative binding through the lens of the weather prediction task.Cognitive, affective & behavioral neuroscience · 2026Article
- The temporal organization of memory and emotion is reciprocally coupled.bioRxiv : the preprint server for biology · 2026Article
- Anger impacts face memory and face - object memory differently in children and adults.Scientific reports · 2026Article
- Dissociable age-dependent effects of emotion on scene and location memory.Scientific reports · 2026Article
- Spatial encoding of a traumatic virtual reality scene reduces intrusive memories.Social cognitive and affective neuroscience · 2026Article
- Neural Patterns Reflect Shared Emotional History.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Latent profiles of emotional perceptions of ageing and health promotion lifestyle in older adults with diabetes: the mediating role of frailty.Journal of diabetes and metabolic disorders · 2025Article
- Valence Effects on Episodic Memory in Young and Old Adults Following Exposure to Emotional Stimuli.The European journal of neuroscience · 2025Article
- Positive affect amplifies integration within episodic memories in the laboratory and the real world.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Dissociating and linking divergent effects of emotion on cognition: insights from current research and emerging directions.Frontiers in psychology · 2025Review
- The rhythm of memory. Does theta frequency audio/visual flicker improve recall?Frontiers in behavioral neuroscience · 2025Article
- Emotional intensity produces a linear relationship on conditioned learning but an inverted U-shaped effect on episodic memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory.Cureus · 2024Review
- The emotion filmmaker: Temporal memory, time-emotion integration, and affective style.Emotion (Washington, D.C.) · 2024Article
- Integrating and fragmenting memories under stress and alcohol.Neurobiology of stress · 2024Article
- Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress.Translational psychiatry · 2024Article
- Disentangling emotional source memory: a mega-analysis on the effects of emotion on item-context binding in episodic long-term memory.Frontiers in psychology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although negative emotion can strengthen memory of an event it can also result in memory disturbances, as in post-traumatic stress disorder (PTSD). We examined the effects of negative item content on amygdalar and hippocampal function in memory for the items themselves and for the associations between them. During fMRI, we examined encoding and retrieval of paired associates made up of all four combinations of neutral and negative images. At test, participants were cued with an image and, if recognised, had to retrieve the associated (target) image. The presence of negative images increased item memory but reduced associative memory. At encoding, subsequent item recognition correlated with amygdala activity, while subsequent associative memory correlated with hippocampal activity. Hippocampal activity was reduced by the presence of negative images, during encoding and correct associative retrieval. In contrast, amygdala activity increased for correctly retrieved negative images, even when cued by a neutral image. Our findings support a dual representation account, whereby negative emotion up-regulates the amygdala to strengthen item memory but down-regulates the hippocampus to weaken associative representations. These results have implications for the development and treatment of clinical disorders in which diminished associations between emotional stimuli and their context contribute to negative symptoms, as in PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.