Evidence map›Paper›PMID 26969671›Full record

ReviewIntensive care medicine2016

Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review.

Laurent Papazian, Amanda Corley, Dean Hess, John F Fraser, Jean-Pierre Frat, Christophe Guitton, Samir Jaber, Salvatore M Maggiore, Stefano Nava, Jordi Rello and 4 more

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 133 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 16 pooled it
32.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04657796 unknown statusnot on this mapstarted 2020, after this paper: background citation

Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan

TypeobservationalSponsorAssiut UniversityRan2020 to 2023Enrolled84ConditionsRespiratory Failure With HypoxiaArmsHigh Flow Nasal Cannula
NCT05692076 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Role of High Velocity Nasal Insufflation in Prevention of Respiratory Complications in Severe Chest Trauma

TypeinterventionalSponsorAssiut UniversityRan2023 to 2025Enrolled86ConditionsChest TraumaArmsHigh Velocity Nasal Insufflation
NCT05910788 naunknown statusnot on this mapstarted 2023, after this paper: background citation

High-Flow Nasal Catheter (HFNC) Compared With Conventional Oxygenation During the Perioperative Period of Patients Undergoing Thoracic Surgery.

TypeinterventionalSponsorFederal University of Rio Grande do SulRan2023 to 2024Enrolled90ConditionsThoracic SurgeryArmshigh flow nasal cannula
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 16 syntheses or guidelines pooled it, 302 citations in OpenAlex.

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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 5 countries.

Laurent PapazianRéanimation des Détresses Respiratoires et Infections Sévères, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Chemin des Bourrely, 13015, Marseille, France. laurent.papazian@ap-hm.fr.
Amanda CorleyCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia.
Dean HessRespiratory Care Department of the Massachusetts General Hospital and the Department of Anesthesia at the Harvard Medical School, Boston, MA, USA.
John F FraserCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia.
Jean-Pierre FratCHU de Poitiers, Réanimation Médicale, Poitiers, France.
Christophe GuittonMedical ICU, Hôtel-Dieu, University Hospital of Nantes, Nantes, France.
Samir JaberDepartment of Critical Care Medicine and Anesthesiology (DAR B), Research Unit INSERM U1046, Saint Eloi University Hospital and Montpellier School of Medicine, 80 Avenue Augustin Fliche, 34295, Montpellier, France.
Salvatore M MaggioreDepartment of Anesthesiology and Critical Care Medicine, Policlinico SS. Annunziata, Università degli Studi "Gabriele d'Annunzio" Chieti-Pescara, Via dei Vestini, 31, 66100, Chieti, Italy.
Stefano NavaDepartment of Specialist, Diagnostic and Experimental Medicine, School of Medicine, Respiratory and Critical Care, Sant'Orsola, Malpighi Hospital, Università di Bologna, Bologna, Italy.
Jordi RelloMedicine Department, CIBERES, Universitat Autonoma de Barcelona, Ps Vall d'Hebron 119, Anexe AG-5a Planta, 08035, Barcelona, Spain.
Jean-Damien RicardAP-HP, Hôpital Louis Mourier, Service de Réanimation Médico-Chirurgicale, 178 rue des Renouillers, 92700, Colombes, France.
François StephanService de Réanimation adulte, Hôpital Marie Lannelongue, 133 Avenue de la Résistance, 92350, Le Plessis-Robinson, France.
Rocco TrisoliniInterventional Pulmology, Sant'Orsola, Malpighi Hospital, Bologna, Italy.
Elie AzoulayAP-HP, Hôpital Saint-Louis, Service de Réanimation Médicale, Sorbonne Paris Cité, Paris Diderot University, Paris, France.
University of Queensland · AUAssistance Publique – Hôpitaux de Paris · FRCentre d'Investigation Clinique de Nantes · FRDélégation Paris 7 · FRHarvard University · USHôpital Marie Lannelongue · FRHôpital Nord · FRInserm · FRPoliclinico S.Orsola-Malpighi · ITUniversitat Autònoma de Barcelona · ESUniversité de Poitiers · FRUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxygen therapy can be delivered using low-flow, intermediate-flow (air entrainment mask), or high-flow devices. Low/intermediate-flow oxygen devices have several drawbacks that cause critically ill patients discomfort and translate into suboptimal clinical results. These include limitation of the FiO2 (due to the high inspiratory flow often observed in patients with respiratory failure), and insufficient humidification and warming of the inspired gas. High-flow nasal cannula oxygenation (HFNCO) delivers oxygen flow rates of up to 60 L/min and over the last decade its effect on clinical outcomes has widely been evaluated, such as in the improvement of respiratory distress, the need for intubation, and mortality. Mechanisms of action of HFNCO are complex and not limited to the increased oxygen flow rate. The main aim of this review is to guide clinicians towards evidence-based clinical practice guidelines. It summarizes current knowledge about HFNCO use in ICU patients and the potential areas of uncertainties. For instance, it has been recently suggested that HFNCO could improve the outcome of patients with hypoxemic acute respiratory failure. In other settings, research is ongoing and additional evidence is needed. For instance, if intubation is required, studies suggest that HFNCO may help to improve preoxygenation and can be used after extubation. Likewise, HFNCO might be used in obese patients, or to prevent respiratory deterioration in hypoxemic patients requiring bronchoscopy, or for the delivery of aerosol therapy. However, areas for which conclusive data exist are limited and interventions using standardized HFNCO protocols, comparators, and relevant clinical outcomes are warranted.

Indexed as

AdultBronchoscopyCannulaCritical IllnessHumansHypoxiaIntensive Care UnitsIntubation, IntratrachealObesityOxygenOxygen Inhalation TherapyRandomized Controlled Trials as TopicRespiratory InsufficiencyTreatment OutcomeOxygenAcute respiratory failureAerosolBronchoscopyHigh-flow nasal cannula oxygenationNon-invasive ventilationOxygen therapy

Identifiers

PMID26969671
OpenAlexW2296109081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.