Evidence map›Paper›PMID 26969660›Full record

Trial reportSurgical endoscopy2016

Prospective, randomized and controlled trial on magnesium sulfate administration during laparoscopic gastrectomy: effects on surgical space conditions and recovery profiles.

J H Ryu, B W Koo, B G Kim, A Y Oh, H H Kim, D J Park, C M Lee, S T Kim, S H Do

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

J H RyuDepartment of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea.
B W KooDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea.
B G KimDepartment of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea.
A Y OhDepartment of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea.
H H KimDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.
D J ParkDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.
C M LeeDepartment of Surgery, Korea University College of Medicine, Seoul, South Korea.
S T KimDepartment of Anesthesiology and Pain Medicine, Chungbuk National University College of Medicine, Cheongjoo, South Korea.
S H DoDepartment of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea. shdo@snu.ac.kr.
Seoul National University Bundang Hospital · KRSeoul National University · KRChungbuk National University · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe degree of neuromuscular blockade is one of the important factors that determine the condition of surgical space during laparoscopic surgery. Magnesium sulfate potentiates the actions of neuromuscular blocking agent, and we hypothesized that intraoperative magnesium sulfate infusion may improve surgical space condition during laparoscopic surgery.

methodsEighty-four patients undergoing elective laparoscopic gastrectomy were randomized to receive isotonic saline (group C) or magnesium sulfate (group M, loading dose with 50 mg/kg over 10 min and then 15 mg/kg/h by continuous infusion) to maintain the moderate neuromuscular blockade using rocuronium. Two experienced surgeons scored the quality of surgical space condition using a 5-point surgical rating scale (SRS). The secondary outcomes included recovery profiles, postoperative pain and adverse events.

resultsThe SRS in group M was higher than that of group C. The proportion of patients with a SRS of 5 (optimal) was 2.7 % in the group C and 40.5 % in the group M (P < 0.0001) although a lower amount of rocuronium was required in group M than group C [24.2 (6.5) mg/h for group M vs. 27.5 (6) mg/h for group C; P = 0.017]. Pain after operation site was less severe in group M than in group C at postoperative 24 h (P = 0.009). Recovery profiles and adverse events were similar between the two groups.

conclusionIntraoperative administration of magnesium sulfate improved the quality of surgical space conditions and decreased neuromuscular blocking agent requirement and postoperative pain in patients undergoing laparoscopic gastrectomy.

Indexed as

GastrectomyLaparoscopyAndrostanolsDouble-Blind MethodFemaleHumansIntraoperative CareMagnesium SulfateMaleMiddle AgedNeuromuscular BlockadeNeuromuscular Blocking AgentsNeuromuscular Nondepolarizing AgentsPneumoperitoneum, ArtificialPostoperative PainProspective StudiesAndrostanolsMagnesium SulfateNeuromuscular Blocking AgentsNeuromuscular Nondepolarizing AgentsRocuroniumLaparoscopic surgeryMagnesium sulfateNeuromuscular blockadeSurgical space condition

Identifiers

PMID26969660
OpenAlexW2294889715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.