ArticleScandinavian journal of trauma, resuscitation and emergency medicine2016
Fibrinogen levels in trauma patients during the first seven days after fibrinogen concentrate therapy: a retrospective study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial.Trials · 2017Trial
- Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis.Journal of thrombosis and haemostasis : JTH · 2026Article
- Platelet count, fibrinogen and ROTEM® parameters predict deep vein thrombosis in elderly patients with femoral fracture.Journal of anesthesia, analgesia and critical care · 2026Article
- Thrombocytopenia and Anemia After Cardiac Surgery.American journal of hematology · 2025Article
- Safety of Fibrinogen Concentrate for Correcting Perioperative Bleeding-Associated Hypofibrinogenemia in Adults: A Single-Center Experience.Journal of clinical medicine · 2024Article
- Experimental Models of Traumatic Injuries: Do They Capture the Coagulopathy and Underlying Endotheliopathy Induced by Human Trauma?International journal of molecular sciences · 2023Review
- [The chapters "Stop the bleed-prehospital" and "Coagulation management and volume therapy (emergency departement)" in the new S3 guideline "Polytrauma/severe injury treatment"].Notfall & rettungsmedizin · 2023Review
- Factor XIII Measurement and Substitution in Trauma Patients after Admission to an Intensive Care Unit.Journal of clinical medicine · 2022Article
- Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Review
- Isolated liver trauma: A clinical perspective in a non-emergency center for liver surgery.Experimental and therapeutic medicine · 2022Article
- Management of Coagulopathy in Bleeding Patients.Journal of clinical medicine · 2021Review
- Emergency Blood Transfusion for Trauma and Perioperative Resuscitation: Standard of Care.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Review
- Therapeutic Application of Fibrinogen in Spine Surgery: A Review Article.International journal of spine surgery · 2021Article
- Fibrinogen Early In Severe Trauma studY (FEISTY): results from an Australian multicentre randomised controlled pilot trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
- Polymorphism rs2066865 in theMedicina (Kaunas, Lithuania) · 2019Observational
- The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.Critical care (London, England) · 2019Article
- Treatment of Obstetric Hemorrhage with Fibrinogen Concentrate.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- [Hypovolemic and hemorrhagic shock].Der Anaesthesist · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibrinogen concentrate (FC) is increasingly used as first line therapy in bleeding trauma patients. It remains unproven whether FC application increases post-traumatic plasma fibrinogen concentration (FIB) in injured patients, possibly constituting a prothrombotic risk. Thus, we investigated the evolution of FIB following trauma in patients with or without FC therapy.
methodsAt the AUVA Trauma Centre, Salzburg, we performed a retrospective study of patients admitted to the emergency room and whose FIB levels were documented thereafter up to day 7 post-trauma. Patients were categorized into those with (treatment group) or without (control group) FC therapy during the first 24 h after hospital admission. A subgroup analysis was carried out to investigate the influence of the amount of FC given.
resultsThe study enrolled 435 patients: treatment group, n = 242 (56 %); control group, n = 193 (44%), with median Injury Severity Score of 34 vs. 22 (P < 0.001) and massive transfusion rate of 18.4% vs. 0.2% (P < 0.001). In the treatment group (median FC dose 6 g), FIB was lower on admission and up to day 2 compared with the control group. In patients receiving high (≥10 g) doses of FC, FIB was lower up to day 5 as compared to controls. At other timepoints, FIB did not differ significantly between the groups. In the treatment vs. the control group, other coagulation parameters such as prothrombin time index and platelet count were consistently lower, while activated partial thromboplastin time was consistently prolonged at most timepoints. Inflammatory parameters such as C-reactive protein, interleukin-6 and procalcitonin were generally lower in controls. DISCUSSION: The rise of FIB levels from day 2 onwards in our study can be attributed to an upregulated fibrinogen synthesis in the liver, occurring in both study groups as part of the acute phase response after tissue injury.
conclusionsThe treatment of severe trauma patients with FC during bleeding management in the first 24 h after hospital admission does not lead to higher FIB levels post-trauma beyond that occurring naturally due to the acute phase response.
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