ArticleBMC research notes2016
Intracerebroventricular administration of chondroitinase ABC reduces acute edema after traumatic brain injury in mice.
Article in BMC research notes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue.Annals of biomedical engineering · 2025Article
- The potential of gene delivery for the treatment of traumatic brain injury.Journal of neuroinflammation · 2024Review
- Acute brain slice elastic modulus decreases over time.Scientific reports · 2023Article
- Proteoglycans and glycosaminoglycans in central nervous system injury.American journal of physiology. Cell physiology · 2022Review
- Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes.Disease models & mechanisms · 2021Article
- Hyaluronidase reduced edema after experimental traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Overexpression of the Aryl Hydrocarbon Receptor (Ahr) Mediates an Oxidative Stress Response following Injection of Fine Particulate Matter in the Temporal Cortex.Oxidative medicine and cellular longevity · 2020Article
- Biomechanical simulation of traumatic brain injury in the rat.Clinical biomechanics (Bristol, Avon) · 2019Review
- Extracellular matrix and traumatic brain injury.Journal of neuroscience research · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBrain edema is a significant challenge facing clinicians managing severe traumatic brain injury (TBI) in the acute period. If edema reaches a critical point, it leads to runaway intracranial hypertension that, in turn, leads to severe morbidity or death if left untreated. Clinical data on the efficacy of standard interventions is mixed. The goal of this study was to validate a novel therapeutic strategy for reducing post-traumatic brain edema in a mouse model. Prior in vitro work reported that the brain swells due to coupled electrostatic and osmotic forces generated by large, negatively charged, immobile molecules in the matrix that comprises brain tissue. Chondroitinase ABC (ChABC) digests chondroitin sulfate proteoglycan, a molecule that contributes to this negative charge. Therefore, we administered ChABC by intracerebroventricular (ICV) injection after controlled cortical impact TBI in the mouse and measured associated changes in edema.
resultsAlmost half of the edema induced by injury was eliminated by ChABC treatment.
conclusionsICV administration of ChABC may be a novel and effective method of treating post-traumatic brain edema in the acute period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.