Evidence map›Paper›PMID 26969574›Full record

SynthesisJournal of nephrology2017

Risk of recurrence of idiopathic calcium kidney stones: analysis of data from the literature.

Pietro Manuel Ferraro, Gary C Curhan, Alessandro D'Addessi, Giovanni Gambaro

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Water for preventing urinary stones.The Cochrane database of systematic reviews · 2020
    Pooled it
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  13. Risk Factors for Upper Urinary Tract Stone Recurrence: A Retrospective Study of 247 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2026
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Pietro Manuel FerraroDivision of Nephrology, Fondazione Policlinico A. Gemelli, Catholic University of the Sacred Heart, Via Moscati 31-33, 00168, Rome, Italy. pietromanuel.ferraro@unicatt.it.ORCID http://orcid.org/0000-0002-1379-022X
Gary C CurhanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Alessandro D'AddessiDivision of Urology, Fondazione Policlinico A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy.
Giovanni GambaroDivision of Nephrology, Fondazione Policlinico A. Gemelli, Catholic University of the Sacred Heart, Via Moscati 31-33, 00168, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNephrolithiasis is a frequent condition. While it is generally accepted that such condition carries a risk of recurrence over time, the exact risk and its predictors have been rarely quantitated. We aimed to estimate recurrence of kidney stones, overall and in specific subgroups, from randomized controlled trials (RCTs) of calcium stone formers.

methodsSystematic review of RCTs of adult patients with idiopathic calcium kidney stones. Recurrence rates analyzed in subgroups based on type of intervention and other characteristics, using Poisson regression models.

resultsThe analysis included 21 RCTs with 2168 participants over a median follow-up of 3.2 years (range 0.5-9.7). The median recurrence of kidney stones was 15 per 100 person-years (range 0-110). Recurrence was higher in those with two or more previous stone episodes compared to those with a single episode at enrolment (16 vs. 6 per 100 person-years, p < 0.001) and in those untreated or treated with dietary changes compared to those treated with drugs (26 vs. 23 vs. 9 per 100 person-years, p < 0.001). The effect of drugs on recurrence seemed to be beneficial only among those with two or more previous stone episodes.

conclusionsThe overall recurrence rate of stones depends on factors such as previous stone history and type of treatment. Dietary approaches seem to be more effective among single stone formers, whereas drugs seem to be more effective among recurrent stone formers.

Indexed as

CalciumHumansKidney CalculiRandomized Controlled Trials as TopicRecurrenceRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeCalciumDietRecurrenceTemporal trendsTreatmentUrolithiasis

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.