ArticleClinical oral investigations2017
The effect of different collagen modifications for titanium and titanium nitrite surfaces on functions of gingival fibroblasts.
Article in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Enhancing the Antibacterial and Biointegrative Properties of Microporous Titanium Surfaces Using Various Metal Coatings: A Comparative Study.Prosthesis (Basel, Switzerland) · 2025Article
- Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration.Bioactive materials · 2025Review
- Impact of topography and added TiN-coating on adult human dermal fibroblasts after seeding on titanium surface in-vitro.Journal of biomaterials applications · 2024Article
- Adhesion of retinal cells to gold surfaces by biomimetic molecules.Frontiers in cell and developmental biology · 2024Article
- Progress in Surface Modification of Titanium Implants by Hydrogel Coatings.Gels (Basel, Switzerland) · 2023Review
- Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study.Biomedicines · 2023Article
- Improving dental epithelial junction on dental implants with bioengineered peptides.Frontiers in bioengineering and biotechnology · 2023Article
- Bacterial and Cellular Response to Yellow-Shaded Surface Modifications for Dental Implant Abutments.Biomolecules · 2022Article
- Collagen-Based Osteogenic Nanocoating of Microrough Titanium Surfaces.International journal of molecular sciences · 2022Article
- Notoginsenoside R1 Promotes Migration, Adhesin, Spreading, and Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stromal Cells.Molecules (Basel, Switzerland) · 2022Article
- Article
- Er:YAG laser irradiation enhances bacterial and lipopolysaccharide clearance and human gingival fibroblast adhesion on titanium discs.Scientific reports · 2021Article
- Substrate Materials for Biomolecular Immobilization within Electrochemical Biosensors.Biosensors · 2021Review
- Novel Yttria-Stabilized Zirconium Oxide and Lithium Disilicate Coatings on Titanium Alloy Substrate for Implant Abutments and Biomedical Application.Materials (Basel, Switzerland) · 2020Article
- Biofunctionalization of Microgroove Surfaces with Antibacterial Nanocoatings.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTargeted modifications of the bulk implant surfaces using bioactive agents provide a promising tool for improvement of the long-term bony and soft tissue integration of dental implants. In this study, we assessed the cellular responses of primary human gingival fibroblasts (HGF) to different surface modifications of titanium (Ti) and titanium nitride (TiN) alloys with type I collagen or cyclic-RGDfK-peptide in order to define a modification improving long-term implants in dental medicine. MATERIALS AND
methodsEmploying Ti and TiN implants, we compared the performance of simple dip coating and anodic immobilization of type I collagen that provided collagen layers of two different thicknesses. HGF were seeded on the different coated implants, and adhesion, proliferation, and gene expression were analyzed.
resultsAlthough there were no strong differences in initial cell adhesion between the groups at 2 and 4 hours, we found that all surface modifications induced higher proliferation rates as compared to the unmodified controls. Consistently, gene expression levels of cell adhesion markers (focal adhesion kinase (FAK), integrin beta1, and vinculin), cell differentiation markers (FGFR1, TGFb-R1), extracellular protein markers (type I collagen, vimentin), and cytoskeletal protein marker aktinin-1 were consistently higher in all surface modification groups at two different time points of investigation as compared to the unmodified controls.
conclusionOur results indicate that simple dip coating of Ti and TiN with collagen is sufficient to induce in vitro cellular responses that are comparable to those of more reliable coating methods like anodic adsorption, chemical cross-linking, or RGD coating. TiN alloys do not possess any positive or adverse effects on HGF. CLINICAL RELEVANCE: Our results demonstrate a simple, yet effective, method for collagen coating on titanium implants to improve the long term integration and stability of dental implants.
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