Evidence map›Paper›PMID 26969392›Full record

ArticleJournal of bone and mineral metabolism2017

Bone resorptive activity of human peripheral blood mononuclear cells after fusion with polyethylene glycol.

Edwin Manrique, Luz M Castillo, Oswaldo Lazala, Carlos A Guerrero, Orlando Acosta

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of bone and mineral metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Edwin ManriqueDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia.
Luz M CastilloDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia.
Oswaldo LazalaDepartamento de Ortopedia, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
Carlos A GuerreroDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia. caguerrerof@unal.edu.co.
Orlando AcostaDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia.
Universidad Nacional de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone remodeling process occurs through bone formation by osteoblasts and bone resorption by osteoclasts, a process involving the contribution of endocrine and nervous systems. The mechanisms associated to differentiation and proliferation of osteoclasts and osteoblasts are considered a potential therapeutic target for treating some erosive bone diseases. The aim of the present study is to explore the feasibility of generating active osteoclast-like cells from peripheral blood mononuclear cells (PBMCs) following polyethylene glycol (PEG)-induced fusion. PEG-fused PBMCs showed TRAP

Indexed as

AdolescentB-LymphocytesBone ResorptionCell Culture TechniquesCell FusionCells, CulturedChildDexamethasoneDiphosphonatesHumansLeukocytes, MononuclearMacrophage Colony-Stimulating FactorMonocytesOsteoblastsOsteoclastsOsteogenesis ImperfectaACP5 protein, humanDexamethasoneDiphosphonatesMacrophage Colony-Stimulating FactorPolyethylene GlycolsTartrate-Resistant Acid PhosphataseBone resorptionMonocyte fusionOsteoclast activityPeripheral blood mononuclear cellsPolyethylene glycol

Identifiers

PMID26969392
OpenAlexW2336038077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.