Evidence map›Paper›PMID 26969168›Full record

ArticleAnnals of intensive care2016

Neuromuscular electrical stimulation acutely mobilizes endothelial progenitor cells in critically ill patients with sepsis.

Christos Stefanou, Eleftherios Karatzanos, Georgios Mitsiou, Katerina Psarra, Epameinondas Angelopoulos, Stavros Dimopoulos, Vasiliki Gerovasili, Efstathios Boviatsis, Christina Routsi, Serafeim Nanas

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03193164 nasuspendednot on this mapstarted 2018, after this paper: background citation

Effects of Physical Therapy With Neuromuscular Electrical Stimulation in Patients With Septic Shock: a Randomised Crossover Clinical Trial Protocol.

TypeinterventionalSponsorUniversity of Sao PauloRan2018 to 2021Enrolled31ConditionsShock, SepticArmsNeuromuscular Electrical Stimulation, Decubitus Position with the limbs raised to 20º
NCT07188350 narecruitingnot on this mapstarted 2025, after this paper: background citation

Neuromuscular Electrical Stimulation of Lower Limbs in Patients Undergoing Invasive Mechanical Ventilation: Randomized Clinical Trial

TypeinterventionalSponsorHospital Moinhos de VentoRan2025 to 2027Enrolled150ConditionsMechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness ConditionArmsConventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  15. Mobilization of endothelial progenitor cells in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Christos Stefanou1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Eleftherios Karatzanos1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Georgios Mitsiou1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Katerina PsarraImmunology and Histocompatibility Department, Evangelismos General Hospital, 45-47 Ypsilantou Str, 106 75, Athens, Greece.
Epameinondas Angelopoulos1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Stavros Dimopoulos1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Vasiliki Gerovasili1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Efstathios Boviatsis2nd Neurosurgical Department, Attiko University General Hospital, School of Medicine, National and Kapodistrian University of Athens, 1 Rimini Str, 124 62, Athens, Greece.
Christina Routsi1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece.
Serafeim Nanas1st Critical Care Department, Evangelismos General Hospital, School of Medicine, National and Kapodistrian University of Athens, 45-47 Ypsilantou Str., 106 75, Athens, Greece. a.icusn@gmail.com.
Evangelismos Hospital · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndothelial progenitor cells (EPCs) have been suggested to constitute a restoration index of the disturbed endothelium in ICU patients. Neuromuscular electric stimulation (NMES) is increasingly employed in ICU to prevent comorbidities such as ICU-acquired weakness, which is related to endothelial dysfunction. The role of NMES to mobilize EPCs has not been investigated yet. The purpose of this study was to explore the NMES-induced effects on mobilization of EPCs in septic ICU patients.

methodsThirty-two septic mechanically ventilated patients (mean ± SD, age 58 ± 14 years) were randomized to one of the two 30-min NMES protocols of different characteristics: a high-frequency (75 Hz, 6 s on-21 s off) or a medium-frequency (45 Hz, 5 s on-12 s off) protocol both applied at maximally tolerated intensity. Blood was sampled before and immediately after the NMES sessions. Different EPCs subpopulations were quantified by cytometry markers CD34(+)/CD133(+)/CD45(-), CD34(+)/CD133(+)/CD45(-)/VEGFR2 (+) and CD34(+)/CD45(-)/VEGFR2 (+).

resultsOverall, CD34(+)/CD133(+)/CD45(-) EPCs increased from 13.5 ± 10.2 to 20.8 ± 16.9 and CD34(+)/CD133(+)/CD45(-)/VEGFR2 (+) EPCs from 3.8 ± 5.2 to 6.4 ± 8.5 cells/10(6) enucleated cells (mean ± SD, p < 0.05). CD34(+)/CD45(-)/VEGFR2 (+) EPCs also increased from 16.5 ± 14.5 to 23.8 ± 19.2 cells/10(6) enucleated cells (mean ± SD, p < 0.05). EPCs mobilization was not affected by NMES protocol and sepsis severity (p > 0.05), while it was related to corticosteroids administration (p < 0.05).

conclusionsNMES acutely mobilized endothelial progenitor cells, measures of the endothelial restoration potential, in septic ICU patients.

Indexed as

Acute effectCritical illnessEarly rehabilitationElectrical muscle stimulationEPCNMES

Identifiers

PMID26969168
PMCPMC4788669
OpenAlexW2294081469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.