Evidence map›Paper›PMID 26969084›Full record

ArticleHaematologica2016

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19.

Hetty H Helsmoortel, Barbara De Moerloose, Tim Pieters, Farzaneh Ghazavi, Silvia Bresolin, Hélène Cavé, Andrica de Vries, Valerie de Haas, Christian Flotho, Veerle Labarque and 13 more

Open access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Regulation of HSC development and function by Lin28b.Frontiers in cell and developmental biology · 2025
    Review
  2. Article
  3. Article
  4. Aberrant stem cell and developmental programs in pediatric leukemia.Frontiers in cell and developmental biology · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Physiological and Aberrant γ-Globin Transcription During Development.Frontiers in cell and developmental biology · 2021
    Review
  10. The Role ofCancers · 2020
    Review
  11. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. The human fetal thymus generates invariant effector γδ T cells.The Journal of experimental medicine · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 7 countries.

Hetty H HelsmoortelDepartment of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium Center for Medical Genetics, Ghent University, Belgium.
Barbara De MoerlooseDepartment of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.
Tim PietersCenter for Medical Genetics, Ghent University, Belgium Unit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium Department of Biomedical Molecular Biology, Ghent University, Belgium.
Farzaneh GhazaviDepartment of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium Center for Medical Genetics, Ghent University, Belgium.
Silvia BresolinDepartment of Women and Child Health, University of Padova, Italy.
Hélène CavéDepartment of Genetics, University Hospital of Robert Debré and Paris-Diderot University, Paris, France.
Andrica de VriesDepartment of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
Valerie de HaasDutch Childhood Oncology Group (DCOG), the Hague, the Netherlands.
Christian FlothoDepartment of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany.
Veerle LabarquePediatric Haemato-Oncology, University Hospitals Leuven, Belgium.
Charlotte NiemeyerDepartment of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Germany.
Pascale De PaepePathological Anatomy, AZ Sint Jan Bruges, Belgium.
Nadine Van RoyCenter for Medical Genetics, Ghent University, Belgium.
Jan StaryDepartment of Paediatric Haematology/Oncology, Charles University and University Hospital Motol, Prague, Czech Republic.
Marry M van den Heuvel-EibrinkDutch Childhood Oncology Group (DCOG), the Hague, the Netherlands Princess Maxima Center for Paediatric Oncology, Utrecht, the Netherlands.
Yves BenoitDepartment of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.
Johannes SchulteDivision of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Paediatric Oncology and Haematology, University Children's Hospital Essen, Essen, Germany German Consortium for Translational Cancer Research (DKTK), Essen, Germany Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Germany Centre for Medical Biotechnology, University Duisburg-Essen, Germany.
Steven GoossensUnit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium Department of Biomedical Molecular Biology, Ghent University, Belgium.
Geert BerxUnit for Molecular and Cellular Oncology, VIB Inflammation Research Center, Ghent University, Belgium Department of Biomedical Molecular Biology, Ghent University, Belgium.
Jody J HaighMammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Frank SpelemanCenter for Medical Genetics, Ghent University, Belgium.
Pieter Van VlierbergheCenter for Medical Genetics, Ghent University, Belgium.
Tim LammensDepartment of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium Tim.Lammens@UGent.be.
Ghent University Hospital · BEVIB-UGent Center for Inflammation Research · BEUniversity of Freiburg · DEAustralian Centre for HIV and Hepatitis Virology Research · AUAZ Sint-Jan · BECharles University · CZErasmus MC - Sophia Children’s Hospital · NLGerman Cancer Research Center · DEPrincess Máxima Center · NLStichting Kinderoncologie Nederland · NLUniversité Paris Cité · FRUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, LeukemicAdolescentChildChild, PreschoolFemaleHumansInfantLeukemiaMaleNeoplasm ProteinsRNA-Binding ProteinsRNA, Long NoncodingRNA, NeoplasmH19 long non-coding RNALIN28B protein, humanNeoplasm ProteinsRNA-Binding ProteinsRNA, Long NoncodingRNA, NeoplasmIncRNA H19 regulationLIN28B overexpressionpediatric leukemia

Identifiers

PMID26969084
PMCPMC5013963
OpenAlexW2409661324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.