Evidence map›Paper›PMID 26968863›Full record

SynthesisLangenbeck's archives of surgery2016

Indocyanine green fluorescence angiography for intraoperative assessment of gastrointestinal anastomotic perfusion: a systematic review of clinical trials.

Thea Helene Degett, Helene Schou Andersen, Ismail Gögenur

4 registry-linked trialsAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Langenbeck's archives of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 99 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 7 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04695184 naunknown statusnot on this mapstarted 2019, after this paper: background citation

The Value of Subjective Near-infrared Fluorescence Guidance in Assessment of Perfusion During Restorative Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2019 to 2021Enrolled50ConditionsUlcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous PolyposisArmsICG-NIRF Imaging
NCT04695964 naunknown statusnot on this mapstarted 2019, after this paper: background citation

The Value of Objective Perfusion Rate Assessment by Near-infrared Fluorescence During Restorative Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2019 to 2021Enrolled50ConditionsUlcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous PolyposisArmsICG-NIRF Imaging plus ingress and egress analysis
NCT04709445 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Objective Perfusion Rate Assessment of Gastrointestinal Anastomoses by Inflow and Outflow Analysis of Near-infrared Fluorescence Agents

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2020 to 2021Enrolled100ConditionsBowel Obstruction, Bowel Ischemia, Diverticulitis, Abnormality of the Gastrointestinal TractArmsICG-NIRF Imaging plus ingress and egress analysis
NCT06198400 narecruitingnot on this mapstarted 2024, after this paper: background citation

Indocyanine Green Fluorescence in Evaluation of Post-resection Pancreatic Remnant Perfusion After Pancreaticoduodenectomy

TypeinterventionalSponsorCharles University, Czech RepublicRan2024 to 2027Enrolled60ConditionsPancreatic FistulaArmsPerioperative assessment of the perfusion of post-resection pancreatic remnant using indocyanine green-VerDye
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 7 syntheses or guidelines pooled it, 207 citations in OpenAlex.

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  15. Colour-Guided Surgery: A Conceptual Framework for Multimodal Intraoperative Visualisation-A Narrative Review.The international journal of medical robotics + computer assisted surgery : MRCAS · 2026
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thea Helene DegettCenter for Surgical Science (CSS), Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark. theadegett@gmail.com.ORCID http://orcid.org/0000-0001-8224-6052
Helene Schou AndersenCenter for Surgical Science (CSS), Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark.
Ismail GögenurCenter for Surgical Science (CSS), Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark.
Zealand University Hospital Køge · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnastomotic leakage following gastrointestinal surgery remains a frequent and serious complication associated with a high morbidity and mortality. Indocyanine green fluorescence angiography (ICG-FA) is a newly developed technique to measure perfusion intraoperatively. The aim of this paper was to systematically review the literature concerning ICG-FA to assess perfusion during the construction of a primary gastrointestinal anastomosis in order to predict anastomotic leakage.

methodsThe following four databases PubMed, Scopus, Embase, and Cochrane were independently searched by two authors. Studies were included in the review if they assessed anastomotic perfusion intraoperatively with ICG-FA in order to predict anastomotic leakage in humans.

resultsOf 790 screened papers 14 studies were included in this review. Ten studies (n = 916) involved patients with colorectal anastomoses and four studies (n = 214) patients with esophageal anastomoses. All the included studies were cohort studies. Intraoperative ICG-FA assessment of colorectal anastomoses was associated with a reduced risk of anastomotic leakage (n = 23/693; 3.3 % (95 % CI 1.97-4.63 %) compared with no ICG-FA assessment (n = 19/223; 8.5 %; 95 % CI 4.8-12.2 %). The anastomotic leakage rate in patients with esophageal anastomoses and intraoperative ICG-FA assessment was 14 % (n = 30/214). None of the studies involving esophageal anastomoses had a control group without ICG-FA assessment.

conclusionNo randomized controlled trials have been published. ICG-FA seems like a promising method to assess perfusion at the site intended for anastomosis. However, we do not have the sufficient evidence to determine that the method can reduce the leak rate.

Indexed as

Coloring AgentsFluorescein AngiographyIndocyanine GreenMonitoring, IntraoperativeAnastomosis, SurgicalAnastomotic LeakDigestive System Surgical ProceduresHumansPredictive Value of TestsRisk FactorsColoring AgentsIndocyanine GreenAnastomotic leakageFluorescence angiographyIndocyanine greenIntraoperative assessmentPerfusion assessment

Identifiers

PMID26968863
OpenAlexW2293128325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.