Evidence map›Paper›PMID 26968850›Full record

Trial reportPain medicine (Malden, Mass.)2016

Mindfulness Meditation and Cognitive Behavioral Therapy Intervention Reduces Pain Severity and Sensitivity in Opioid-Treated Chronic Low Back Pain: Pilot Findings from a Randomized Controlled Trial.

Aleksandra E Zgierska, Cindy A Burzinski, Jennifer Cox, John Kloke, Aaron Stegner, Dane B Cook, Janice Singles, Shilagh Mirgain, Christopher L Coe, Miroslav Bačkonja

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain medicine (Malden, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06858202 (Structured Post-Operative Pain and Distress Treatment Intervention for Patients Undergoing Surgery for Intra-Abdominal Malignancies), which is not on this map. Cited by 50 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 16 pooled it
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06858202 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Structured Post-Operative Pain and Distress Treatment Intervention for Patients Undergoing Surgery for Intra-Abdominal Malignancies

TypeinterventionalSponsorUniversity of UtahRan2025 to 2026Enrolled95ConditionsPsychological Distress, Intra-abdominal CancerArmsMindfulness Intervention, Non-mindfulness Intervention
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 16 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. A Systematic Review of the Adherence to Home-Practice Meditation Exercises in Patients with Chronic Pain.International journal of environmental research and public health · 2023
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Brief Mindfulness-Based Interventions for Acute and Chronic Pain: A Systematic Review.Journal of alternative and complementary medicine (New York, N.Y.) · 2019
    Pooled it
  16. Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017
    Pooled it
  17. Trial
  18. Trial
  19. Trial
  20. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Aleksandra E ZgierskaDepartment of *Family Medicine and Community Health, aleksandra.zgierska@fammed.wisc.edu.
Cindy A BurzinskiDepartment of *Family Medicine and Community Health.
Jennifer CoxDepartment of *Family Medicine and Community Health.
John KlokeDepartment of Biostatistics and Medical Informatics.
Aaron StegnerDepartment of Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
Dane B CookDepartment of Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
Janice SinglesDepartment of Orthopedics and Rehabilitation.
Shilagh MirgainDepartment of Orthopedics and Rehabilitation.
Christopher L CoeDepartment of Harlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, Wisconsin.
Miroslav BačkonjaDepartment of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison,Wisconsin.
University of Wisconsin–Madison · USInstitute for Medical Informatics and Biostatistics · CHWilliam S. Middleton Memorial Veterans Hospital · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Mindfulness Meditation for Alcohol Relapse PreventionK23AA017508 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI ZGIERSKA, ALEKSANDRA EWA · 2009 to 2013
$918k
NCATS NIH HHS UL1 TR000427NIAAA NIH HHS K23 AA017508
6 · The paper itself

Abstract

objectiveTo assess benefits of mindfulness meditation and cognitive behavioral therapy (CBT)-based intervention for opioid-treated chronic low back pain (CLBP).

design26-week parallel-arm pilot randomized controlled trial (Intervention and Usual Care versus Usual Care alone).

settingOutpatient. SUBJECTS: Adults with CLBP, prescribed ≥30 mg/day of morphine-equivalent dose (MED) for at least 3 months.

methodsThe intervention comprised eight weekly group sessions (meditation and CLBP-specific CBT components) and 30 minutes/day, 6 days/week of at-home practice. Outcome measures were collected at baseline, 8, and 26 weeks: primary-pain severity (Brief Pain Inventory) and function/disability (Oswestry Disability Index); secondary-pain acceptance, opioid dose, pain sensitivity to thermal stimuli, and serum pain-sensitive biomarkers (Interferon-γ; Tumor Necrosis Factor-α; Interleukins 1ß and 6; C-reactive Protein).

resultsThirty-five (21 experimental, 14 control) participants were enrolled and completed the study. They were 51.8 ± 9.7 years old, 80% female, with severe CLBP-related disability (66.7 ± 11.4), moderate pain severity (5.8 ± 1.4), and taking 148.3 ± 129.2 mg/day of MED. Results of the intention-to-treat analysis showed that, compared with controls, the meditation-CBT group reduced pain severity ratings during the study (P = 0.045), with between-group difference in score change reaching 1 point at 26 weeks (95% Confidence Interval: 0.2,1.9; Cohen's d = 0.86), and decreased pain sensitivity to thermal stimuli (P < 0.05), without adverse events. Exploratory analyses suggested a relationship between the extent of meditation practice and the magnitude of intervention benefits.

conclusionsMeditation-CBT intervention reduced pain severity and sensitivity to experimental thermal pain stimuli in patients with opioid-treated CLBP.

Indexed as

AdultAnalgesics, OpioidChronic PainCognitive Behavioral TherapyFemaleHot TemperatureHumansLow Back PainMaleMeditationMiddle AgedMindfulnessPain MeasurementPilot ProjectsSeverity of Illness IndexSingle-Blind MethodAnalgesics, OpioidChronic Low Back PainCognitive Behavioral TherapyLong-Term Opioid TherapyMindfulness Meditation

Identifiers

PMID26968850
PMCPMC5063022
OpenAlexW2293891873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.