Evidence map›Paper›PMID 26968807›Full record

Trial reportBrain stimulation

Reduced Affective Biasing of Instrumental Action With tDCS Over the Prefrontal Cortex.

Verena Ly, Til O Bergmann, Thomas E Gladwin, Inge Volman, Niccolo Usberti, Roshan Cools, Karin Roelofs

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Verena LyBehavioural Science Institute, Radboud University, 6525 HR Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands. Electronic address: v.ly@donders.ru.nl.
Til O BergmannDonders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands; Department of Psychology, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany; Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany; Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany.
Thomas E GladwinBehavioural Science Institute, Radboud University, 6525 HR Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands; Research Centre - Military Mental Health, Ministry of Defense, 3584 CX Utrecht, The Netherlands.
Inge VolmanBehavioural Science Institute, Radboud University, 6525 HR Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands; Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
Niccolo UsbertiDonders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands.
Roshan CoolsDonders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands; Department of Psychiatry, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Karin RoelofsBehavioural Science Institute, Radboud University, 6525 HR Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6525 EN Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInstrumental action is well known to be vulnerable to affective value. Excessive transfer of affective value to instrumental action is thought to contribute to psychiatric disorders. The brain region most commonly implicated in overriding such affective biasing of instrumental action is the prefrontal cortex.

objectiveThe aim of the present study was to reduce affective biasing of instrumental action using transcranial direct current stimulation (tDCS) in young healthy human volunteers.

methodsIn a double-blind, randomized between-group design, 120 participants received anodal, cathodal and sham tDCS while at the same time (online) performing a task that assessed affective biasing of instrumental action. We placed tDCS electrodes over the anterior part of the prefrontal cortex based on evidence from brain stimulation work demonstrating the role of this brain region in controlling affective biasing of instrumental action.

resultsWe showed that prefrontal tDCS reduced affective biasing of instrumental action. Specifically, prefrontal tDCS reduced the degree to which aversive (versus appetitive) cues potentiated instrumental avoidance and suppressed instrumental approach. Contrary to our hypothesis, this effect was seen for cathodal tDCS rather than anodal tDCS.

conclusionThe results demonstrate the potential utility of prefrontal tDCS as a tool for reducing affective biasing of instrumental behavior, thus opening avenues for interventional research on psychiatric disorders that implicate excessive transfer of affective value.

Indexed as

CuesAdultDecision MakingDouble-Blind MethodFemaleHealthy VolunteersHumansMalePhotic StimulationPrefrontal CortexTranscranial Direct Current StimulationYoung AdultAffective biasesDecision makingEmotionInstrumental actionPrefrontal cortexTranscranial direct current stimulation (tDCS)

Identifiers

PMID26968807
PMCPMC4881415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.