ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2016
Factors influencing the pupillary light reflex in healthy individuals.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Dose Dependent Effects of Atropine on Static and Dynamic Pupil and Accommodation Metrics in Young Adults.Investigative ophthalmology & visual science · 2025Trial
- Pupillometric alterations in Graves' disease: Beyond thyroid functional status.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Pupil Size Reflects Trial-Level Variability in Imagery Vividness During Immersive Storytelling but Not (or Hardly) Individual Differences in Trait Imagery.Psychophysiology · 2026Article
- Participants' characteristics influencing pupillometry parameters in a community in Japan.Fukushima journal of medical science · 2026Article
- No significant modulation of pressure pain sensitivity and cardioception after transauricular vagal nerve stimulation.Pain reports · 2026Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Pupillary Responses and Vital Signs in Hypoglycemic Patients with Impaired Consciousness During Prehospital Care: A Retrospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Examining pupil characteristics and relative afferent pupil defect prevalence in Syrian patients.Annals of medicine and surgery (2012) · 2025Article
- Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.Clinical neurophysiology practice · 2025Article
- Measuring the Pupillary Light Reflex Using Portable Instruments in Applied Settings.Vision (Basel, Switzerland) · 2024Article
- Effect of lighting conditions on implantable collamer lens vault: Influence of anterior chamber and lens parameters.Heliyon · 2024Article
- Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort.Investigative ophthalmology & visual science · 2024Article
- The Role of Concussion History and Biological Sex on Pupillary Light Reflex Metrics in Adolescent Rugby Players: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2024Article
- Machine learning approach for ambient-light-corrected parameters and the Pupil Reactivity (PuRe) score in smartphone-based pupillometry.Frontiers in neurology · 2024Article
- Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults.Journal of physiological anthropology · 2023Review
- Radiology blues: Comparing occupational blue-light exposure to recommended safety standards.SA journal of radiology · 2023Article
- The impact of Alzheimer's disease risk factors on the pupillary light response.Frontiers in neuroscience · 2023Review
- Iris Color Matters-A Contractility Analysis With Dynamic Volume-Rendered Optical Coherence Tomography Pupillometry.Translational vision science & technology · 2022Article
- Do static and dynamic pupillary parameters differ according to childhood, adulthood, and old age? A quantitative study in healthy volunteers.Indian journal of ophthalmology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the ocular anatomical factors influencing the pupillary light reactions to different wavelengths of light, measured with chromatic pupillometry.
methodsCommunity-based, cross-sectional study including subjects with normal ocular health (ages 50-79 years). Direct pupillary responses to continuously increasing irradiances (6.8 to 13.8 log photons cm(-2) s(-1)) of red (631 nm) and blue (469 nm) light were measured, using a dedicated infrared pupillometer. All subjects underwent swept source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) and noncontact partial coherence laser interferometry (Lenstar LS900, Haag-Streit AG, Switzerland). Univariate and multivariable regression analyses were performed to determine the anatomical features influencing pupillographic parameters.
resultsAmong the 177 included subjects, 167 (94.4 %) were Chinese and 116 (65.5 %) female. The average baseline pupil diameter in darkness (β = -0.080, p < 0.001) and the amplitude of the relative pupillary constriction (β = -0.233, p = 0.006) to blue light decreased with age. The amplitude of pupillary constriction was significantly larger in patients with a thinner iris, in response to stimulation with blue (β = -0.321, p < 0.001) and red light (β = -0.336, p < 0.001). Other ocular parameters (i.e., lens vault, anterior chamber depth width, iris volume, iris curvature, and lens thickness) were not significantly associated with pupillometric outcomes.
conclusionsThe amplitude of the pupillary light constriction to chromatic photic stimuli is reduced with increasing age and iris thickness in subjects with normal ocular health, a finding which needs to be integrated into future pupillometric studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.