ReviewBMC infectious diseases2016
Does tuberculosis threaten our ageing populations?
Review in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Inequalities in the impact of COVID-19-associated disruptions on tuberculosis diagnosis by age and sex in 45 high TB burden countries.BMC medicine · 2022Pooled it
- Tuberculosis Development in Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Study.Journal of Korean medical science · 2026Article
- Comorbidity profiles and their impact on treatment outcomes in elderly patients with pulmonary tuberculosis: a single-center retrospective cohort study.BMC infectious diseases · 2026Article
- Spatio-temporal modeling of tuberculosis among Brazil's elderly: a 20-year ecological and population-based study.BMC infectious diseases · 2026Article
- Optimizing Quality of Care for Elderly Tuberculosis Patients in Shanghai, China: Insights from Patient Cascade of Care and Patient Pathway Analysis.Tropical medicine and infectious disease · 2026Article
- Prevalence, risk factors, and rifampicin resistance pattern ofParasite epidemiology and control · 2026Article
- Risk Factors for False-Negative T-SPOT.TB Results in Bacteriologically Confirmed Pulmonary Tuberculosis: A Retrospective Cohort Study of 4,931 Patients.Infection and drug resistance · 2026Article
- Tuberculosis: An Ongoing Global Threat.Advances in experimental medicine and biology · 2026Review
- The impact of population ageing on tuberculosis incidence, mortality, and case fatality in South Korea: a nationwide retrospective study.ERJ open research · 2025Article
- Molecular Epidemiology ofMicroorganisms · 2025Review
- The impact of population aging on tuberculosis prevention and control in Shanghai: a prediction based on age-period-cohort models.Aging clinical and experimental research · 2025Article
- Tuberculosis Incidence and Outcomes Among Older New Yorkers.Open forum infectious diseases · 2025Article
- Depressive episode and treatment outcomes in elderly individuals with tuberculosis: A prospective cohort study in Korea.PloS one · 2025Article
- The influence and lag-effect of temperature and precipitation on the incidence and mortality of tuberculosis, 2000-2021: an observational study.Frontiers in public health · 2025Observational
- Epidemiology and Molecular Drug-Resistance Patterns of Tuberculosis in Non-Elderly Patients in Luoyang, China, 2019-2023.Infection and drug resistance · 2025Article
- Effect of population aging on pulmonary tuberculosis burden in Zhejiang Province, China: a population-based study.Frontiers in public health · 2025Article
- Epidemiology of Latent Tuberculosis in Moroccan Healthcare Workers: Prevalence Patterns and Predisposing Factors.Cureus · 2024Article
- A retrospective study of zoonotic tuberculosis among livestock farmers of Lahore district using one health approach.Journal of advanced veterinary and animal research · 2024Article
- Malnutrition and unsuccessful tuberculosis treatment among people with multi-drug resistant tuberculosis in Uganda: A retrospective analysis.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe global population is ageing quickly and our understanding of age-related changes in the immune system suggest that the elderly will have less immunological protection from active tuberculosis (TB). DISCUSSION: Ongoing global surveillance of TB notifications shows increasing age of patients with active TB. This effect of age is compounded by changes to clinical manifestations of disease, confounding of diagnostic tests and increased rates of adverse reactions to antimicrobial treatment of TB. Future epidemiological surveillance, development of diagnostic tests and trials of treatment shortening should all include a focus on ageing people. More detailed surveillance of TB notifications in elderly people should be undertaken and carefully evaluated. Risk stratification will help target care for those in greatest need, particularly those with comorbidities or on immunosuppressive therapies. Novel diagnostics and treatment regimes should be designed specifically to be used in this cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.