ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2017
Exportation and Validation of Latent Constructs for Dementia Case Finding in a Mexican American Population-based Cohort.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02878538 (An N of One Clinical Trial to Pilot the Feasibility of Using the Iron-Chelator Deferiprone on Mild Cognitive Impairment), which is not on this map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An N of One Clinical Trial to Pilot the Feasibility of Using the Iron-Chelator Deferiprone on Mild Cognitive Impairment
Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Observational
- Intelligence, cognition, and major neurocognitive disorders: From constructs to measures.Cerebral circulation - cognition and behavior · 2023Article
- Online Clinical Consensus Diagnosis of Dementia: Development and Validation.Journal of the American Geriatrics Society · 2020Article
- Article
- Article
- The effectiveness and unique contribution of neuropsychological tests and the δ latent phenotype in the differential diagnosis of dementia in the uniform data set.Neuropsychology · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
backgroundThe latent variable "δ" has been validated as a dementia phenotype. δ can be extracted from Spearman's general intelligence factor "g" in any data set that contains measures of cognition and instrumental activities of daily living (IADL). We used δ composites ("d-scores") to estimate the prevalence of dementia in the Hispanic Established Population for Epidemiological Studies in the Elderly (H-EPESE).
methodδ was constructed from Mini-Mental State Examination, a clock-drawing task (CLOX), and IADL. δ's H-EPESE factor weights were validated in the well-characterized Texas Alzheimer's Research and Care Consortium (TARCC). Optimal thresholds for the discrimination between "Alzheimer's disease" (AD) versus normal controls (NCs) were determined by receiver operating characteristic curve. Those thresholds were used to estimate the prevalence of dementia in H-EPESE.
resultsEach δ homolog fits its source's data well. d-scores were strongly associated with Clinical Dementia Rating scale Sum of Boxes (r = .74-.85, all p < .001], and accurately distinguished AD cases from NCs, in both Mexican Americans (MAs) and non-Hispanic Whites (NHWs) [c = 0.94-0.96]. The TARCC MA threshold estimated the prevalence of dementia at 21.4% in H-EPESE. The NHW threshold estimated the prevalence of dementia at 21.0%.
conclusionsIt is possible to export δ composites from populations to well-characterized cohorts for validation.
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