ArticleContemporary clinical trials2016
Optimizing operational efficiencies in early phase trials: The Pediatric Trials Network experience.
Article in Contemporary clinical trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Furosemide Safety in Preterm Infants at Risk for Bronchopulmonary Dysplasia: A Randomized Clinical Trial.The Journal of pediatrics · 2025Trial
- Population pharmacokinetic modeling and simulation-informed ceftazidime dosing in Chinese neonates using quantitative dried blood spot micro-sampling.Antimicrobial agents and chemotherapy · 2026Article
- Pharmacokinetics and Safety of Ustekinumab in Patients with Juvenile Psoriatic Arthritis: Results of the Real-World Ustekinumab Pediatric Opportunistic Pharmacokinetics Study (U-POPS).Rheumatology and therapy · 2026Article
- Harmonizing Quality Improvement Metrics Across Global Trial Networks to Advance Paediatric Clinical Trials Delivery.Therapeutic innovation & regulatory science · 2024Article
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- An Innovative Approach to Building an Effective and Efficient Pediatric Trial Network.Hospital pediatrics · 2022Article
- Exposure-safety relationship for acyclovir in the treatment of neonatal herpes simplex virus disease.Early human development · 2022Article
- Current situation of pediatric clinical trials in China: focus on trials for drug marketing application and administrative approval.BMC pediatrics · 2022Observational
- Capacity Building in a New Clinical Trials Network through Inter-Network Collaboration.The Journal of pediatrics · 2022Article
- Recommendations by the European Network of Paediatric Research at the European Medicines Agency (Enpr-EMA) Working Group on preparedness of clinical trials about paediatric medicines process.Archives of disease in childhood · 2021Review
- Association between neonatal intensive care unit medication safety practices, adverse events, and death.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- IDeA States Pediatric Clinical Trials Network for Underserved and Rural Communities.Pediatrics · 2020Article
- Population Pharmacokinetics and Safety of Piperacillin-Tazobactam Extended Infusions in Infants and Children.Antimicrobial agents and chemotherapy · 2019Article
- Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.Applied clinical informatics · 2019Article
- Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study.BMC pregnancy and childbirth · 2018Article
- A directory for neonatal intensive care: potential for facilitating network-based research in neonatology.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Pharmacokinetic studies in children: recommendations for practice and research.Archives of disease in childhood · 2018Review
- Association between oral sildenafil dosing, predicted exposure, and systemic hypotension in hospitalised infants.Cardiology in the young · 2018Article
- Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants.The Pediatric infectious disease journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Performing drug trials in pediatrics is challenging. In support of the Best Pharmaceuticals for Children Act, the Eunice Kennedy Shriver National Institute of Child Health and Human Development funded the formation of the Pediatric Trials Network (PTN) in 2010. Since its inception, the PTN has developed strategies to increase both efficiency and safety of pediatric drug trials. Through use of innovative techniques such as sparse and scavenged blood sampling as well as opportunistic study design, participation in trials has grown. The PTN has also strived to improve consistency of adverse event reporting in neonatal drug trials through the development of a standardized adverse event table. We review how the PTN is optimizing operational efficiencies in pediatric drug trials to increase the safety of drugs in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.