ArticleAmerican journal of physiology. Heart and circulatory physiology2016
The influence of acute unloading on left ventricular strain and strain rate by speckle tracking echocardiography in a porcine model.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Association between left ventricular longitudinal function and left atrial strain in left ventricular dysfunction.ESC heart failure · 2026Article
- Characterization of global and regional left heart function using advanced echocardiography following intravenous administration of pimobendan in awake dogs.Frontiers in veterinary science · 2026Article
- Comprehensive echocardiographic protocol for pigs with emphasis on diastolic function: advantages over MRI assessment.American journal of physiology. Heart and circulatory physiology · 2025Article
- Cardiac Magnetic Resonance Imaging with Myocardial Strain Assessment Correlates with Cardiopulmonary Exercise Testing in Patients with Pectus Excavatum.Diagnostics (Basel, Switzerland) · 2024Article
- Myocardial strain is regulated by cardiac preload in the early stage of sepsis.BMC cardiovascular disorders · 2024Article
- 4D ultrasound-based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction.Physiological reports · 2024Article
- Association between speckle tracking echocardiography and pressure-volume loops during cardiogenic shock development.Open heart · 2024Article
- Prognostic Relevance of Global Myocardial Work Index in Patients with Moderate Aortic Valve Stenosis.Journal of clinical medicine · 2023Article
- Effect of maximum exercise on left ventricular deformation and its correlation with cardiopulmonary exercise capacity in competitive athletes.Echo research and practice · 2023Article
- miR-146a-5p, miR-223-3p and miR-142-3p as Potential Predictors of Major Adverse Cardiac Events in Young Patients with Acute ST Elevation Myocardial Infarction-Added Value over Left Ventricular Myocardial Work Indices.Diagnostics (Basel, Switzerland) · 2022Article
- Highlighting the role of global longitudinal strain assessment in valvular heart disease.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022Review
- Novel insights into the athlete's heart: is myocardial work the new champion of systolic function?European heart journal. Cardiovascular Imaging · 2022Article
- Impact of arterio-ventricular interaction on first-phase ejection fraction in aortic stenosis.European heart journal. Cardiovascular Imaging · 2021Article
- Favorable changes of left ventricular function in the circumferential direction following transcatheter atrial septal defect closure: a strain imaging study.The international journal of cardiovascular imaging · 2021Article
- Observational
- Decreased right ventricular longitudinal strain in children with hypoplastic left heart syndrome during staged repair and follow-up: does it have implications in clinically stable patients?The international journal of cardiovascular imaging · 2020Article
- Clinical and Research Tools for the Study of Cardiovascular Effects of Cancer Therapy.Journal of cardiovascular translational research · 2020Review
- Application of strain echocardiography in valvular heart diseases.Anatolian journal of cardiology · 2020Review
- Speckle tracking echocardiography could detect the difference of pressure overload-induced myocardial remodelling between young and adult rats.Journal of the Royal Society, Interface · 2020Article
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7 authors.
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Abstract
Noninvasive measurements of myocardial strain and strain rate by speckle tracking echocardiography correlate to cardiac contractile state but also to load, which may weaken their value as indices of inotropy. In a porcine model, we investigated the influence of acute dynamic preload reductions on left ventricular strain and strain rate and their relation to the pressure-conductance catheter-derived preload recruitable stroke work (PRSW) and peak positive first derivative of left ventricular pressure (LV-dP/dtmax). Speckle tracking strain and strain rate in the longitudinal, circumferential, and radial directions were measured during acute dynamic reductions of end-diastolic volume during three different myocardial inotropic states. Both strain and strain rate were sensitive to unloading of the left ventricle (P < 0.001), but the load dependency for strain rate was modest compared with strain. Changes in longitudinal and circumferential strain correlated more strongly to changes in end-diastolic volume (r = -0.86 and r = -0.72) than did radial strain (r = 0.35). Longitudinal, circumferential, and radial strain significantly correlated with LV-dP/dtmax (r = -0.53, r = -0.46, and r = 0.86), whereas only radial strain correlated with PRSW (r = 0.55). Strain rate in the longitudinal, circumferential and radial direction significantly correlated with both PRSW (r = -0.64, r = -0.58, and r = 0.74) and LV-dP/dtmax (r = -0.95, r = -0.70, and r = 0.85). In conclusion, the speckle tracking echocardiography-derived strain rate is more robust to dynamic ventricular unloading than strain. Longitudinal and circumferential strain could not predict load-independent contractility. Strain rates, and especially in the radial direction, are good predictors of preload-independent inotropic markers derived from conductance catheter.
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