ArticleDrug safety2016
Universal Correction for QT/RR Hysteresis.
Article in Drug safety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- PK/PD modeling of a clazosentan thorough QT study with hysteresis in concentration-QT and RR-QT.Journal of pharmacokinetics and pharmacodynamics · 2021Trial
- Dynamical cross-correlations between RR and QT intervals in long-term electrocardiogram recordings.Scientific reports · 2026Article
- Direct evaluation of the electrocardiographic spatial QRS-T angle without the need for orthogonal transformation.Scientific reports · 2026Article
- Accurate QT correction method from transfer entropy.Cardiovascular digital health journal · 2023Article
- Conundrum of Clinical QTc Monitoring.Drug safety · 2022Article
- The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.BMC cardiovascular disorders · 2022Article
- Short-Term Beat-to-Beat QT Variability Appears Influenced More Strongly by Recording Quality Than by Beat-to-Beat RR Variability.Frontiers in physiology · 2022Article
- Intra-subject stability of different expressions of spatial QRS-T angle and their relationship to heart rate.Frontiers in physiology · 2022Article
- Influence of heart rate correction formulas on QTc interval stability.Scientific reports · 2021Article
- Spatial distribution of physiologic 12-lead QRS complex.Scientific reports · 2021Article
- Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects.Frontiers in physiology · 2021Article
- Problems with Bazett QTc correction in paediatric screening of prolonged QTc interval.BMC pediatrics · 2020Article
- Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization.British journal of clinical pharmacology · 2020Article
- Sources of QTc variability: Implications for effective ECG monitoring in clinical practice.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Review
- Physiologic heart rate dependency of the PQ interval and its sex differences.Scientific reports · 2020Article
- Heart Rate Dependency and Inter-Lead Variability of the T Peak - T End Intervals.Frontiers in physiology · 2020Article
- Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals.Scientific reports · 2019Article
- Heart Rate Correction of the J-to-Tpeak Interval.Scientific reports · 2019Article
- Implications of Individual QT/RR Profiles-Part 1: Inaccuracies and Problems of Population-Specific QT/Heart Rate Corrections.Drug safety · 2019Article
- Implications of Individual QT/RR Profiles-Part 2: Zero QTc/RR Correlations Do Not Prove QTc Correction Accuracy in Studies of QTc Changes.Drug safety · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionClinical pharmacology QT/QTc studies can be smaller if they more efficiently use the data generated.
objectiveThe aim was to use large sets of electrocardiograms (ECGs) deposited at the US Food and Drug Administration to investigate the implications of heart rate measurement on the accuracy of QTc data.
methodsUsing the data of 80 thorough QT studies, we investigated whether placing study subjects in supine positions during short-term time points stabilizes heart rate (part I, based on 73 studies with 747,912 measured ECGs in 6786 healthy subjects) and whether heart rate measurements different from RR intervals captured simultaneously with QT intervals decrease QTc variability (part II, based on seven studies with 897,570 ECG measurements in 751 healthy subjects).
resultsIn the part I data, when subjects were placed in supine undisturbed positions, heart rate instability (max-min of repeatedly measured heart rates within the same study time point) exceeding 5 beats per minute (bpm) was observed 40 % of the time and exceeded 10 bpm 10 % of the time. In the part II data, even when including QT measurements preceded by variable heart rates, correction of QT durations for RR interval values derived through a simple QT/RR hysteresis model with 95 % adaptation in 120 s led to mean intra-subject standard deviation of QTc (Fridericia formula) of only 7.14 ± 1.98 and 6.38 ± 1.50 ms in women and men, respectively.
conclusionThe QT/RR hysteresis model with 95 % adaptation in 120 s is universally applicable to healthy subjects, providing small QTc variability. Supine positions do not generally stabilize heart rates in healthy subjects. Universally applicable QT/RR hysteresis correction allows clinical QT/QTc studies to include variable heart rate episodes in the time points.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.