ArticleCritical care (London, England)2016
Liver function predicts survival in patients undergoing extracorporeal membrane oxygenation following cardiovascular surgery.
Article in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Understanding the "extracorporeal membrane oxygenation gap" in veno-arterial configuration for adult patients: Timing and causes of death.Artificial organs · 2021Pooled it
- Association of Plasma Biomarkers of Immunothrombosis With Death in Patients With Coronavirus Disease 2019 on Extracorporeal Membrane Oxygenation.The Journal of infectious diseases · 2026Article
- Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation.Clinical pharmacokinetics · 2026Observational
- Severe hyperbilirubinemia secondary to ECMO in a ARDS patient: a case report.Frontiers in medicine · 2026Article
- Association between liver function at hospital admission and mortality in pediatric patients receiving postcardiotomy venoarterial extracorporeal membrane oxygenation support.World journal of emergency medicine · 2025Article
- AI-powered model for predicting mortality risk in VA-ECMO patients: a multicenter cohort study.Scientific reports · 2025Article
- Cardiometabolic shock: understanding the final turns of the downward spiral.Frontiers in cardiovascular medicine · 2025Review
- Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study.Critical care (London, England) · 2024Article
- Optimizing Outcomes in Extracorporeal Membrane Oxygenation Postcardiotomy in Pediatric Population.Journal of pediatric intensive care · 2023Review
- Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy.Journal of thoracic disease · 2023Article
- Oxygen debt repayment in the early phase of veno-arterial extracorporeal membrane oxygenation: a cluster analysis.BMC cardiovascular disorders · 2022Article
- Efficacy of Veno-Arterial Extracorporeal Life Support in Adult Patients with Refractory Cardiogenic Shock.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2022Article
- Serum Total Bilirubin With Hospital Survival in Adults During Extracorporeal Membrane Oxygenation.Frontiers in medicine · 2022Article
- Critically Ill COVID-19 Patient with Chronic Liver Disease - Insights into a Comprehensive Liver Intensive Care.Journal of clinical and translational hepatology · 2021Review
- Liver Dysfunction Associated With In-Hospital Mortality in Adult Extracorporeal Membrane Oxygenation Support.Critical care explorations · 2021Article
- Veno-arterial extracorporeal membrane oxygenation: Special reference for use in 'post-cardiotomy cardiogenic shock' - A review with an Indian perspective.Indian journal of thoracic and cardiovascular surgery · 2021Article
- Extracorporeal Life Support for Cardiac Arrest and Cardiogenic Shock.US cardiology · 2021Review
- Bilirubin-A Possible Prognostic Mortality Marker for Patients with ECLS.Journal of clinical medicine · 2020Article
- Update on Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2020Review
- Structured review of post-cardiotomy extracorporeal membrane oxygenation: part 1-Adult patients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtracorporeal membrane oxygenation (ECMO) represents a valuable and rapidly evolving therapeutic option in patients with severe heart or lung failure following cardiovascular surgery. However, despite significant advances in ECMO techniques and management, prognosis remains poor and accurate risk stratification challenging. We therefore evaluated the predictive value of liver function variables on all-cause mortality in patients undergoing venoarterial ECMO support after cardiovascular surgery.
methodsWe included into our single-center registry a total of 240 patients undergoing venoarterial ECMO therapy following cardiovascular surgery at a university-affiliated tertiary care center.
resultsThe median follow-up was 37 months (interquartile range 19-67 months), and a total of 156 patients (65%) died. Alkaline phosphatase and total bilirubin were the strongest predictors for 30-day mortality, with adjusted hazard ratios (HRs) per 1-standard deviation increase of 1.36 (95% confidence interval [CI] 1.10-1.68; P = 0.004) and 1.22 (95% CI 1.07-1.40; P = 0.004), respectively. The observed associations persisted for long-term mortality, with adjusted HRs of 1.27 (95% CI 1.03-1.56; P = 0.023) for alkaline phosphatase and 1.22 (95% CI 1.07-1.39; P = 0.003) for total bilirubin.
conclusionsThe present study demonstrates that elevated values of alkaline phosphatase and total bilirubin are sensitive parameters for predicting the short-term and long-term outcomes of ECMO patients.
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