ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Multimorbidity Combinations and Disability in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03609658 (Integrated Approach to Patient and Family Engagement for Advance Care Planning for Vulnerable Older Adult Within an Accountable Care Organization), which is not on this map. Cited by 130 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrated Approach to Patient and Family Engagement for Advance Care Planning for Vulnerable Older Adult Within an Accountable Care Organization (ACO)
Who cites it
130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- The prevalence of disability in older adults with multimorbidity: a meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Do morbidity measures predict the decline of activities of daily living and instrumental activities of daily living amongst older inpatients? A systematic review.International journal of clinical practice · 2021Pooled it
- Association of N-butylphthalide treatment with 1-year activities-of-daily-living recovery in convalescent ischemic stroke patients with chronic disease burden: a post-marketing real-world non-randomized controlled study.Frontiers in medicine · 2026Trial
- The Effect of Active Plus, a Computer-Tailored Physical Activity Intervention, on the Physical Activity of Older Adults with Chronic Illness(es)-A Cluster Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- The cost-effectiveness of a telephone-based intervention to support caregivers of older people discharged from hospital.BMC geriatrics · 2019Trial
- Arthritis-diabetes comorbidity and functional recovery in older adults: a longitudinal cohort study using the Health and Retirement Study.Research square · 2026Article
- Disability Among Middle Aged and Older Immigrants: Differences by Citizenship, English Proficiency, and Years in United States.Journal of aging and health · 2026Article
- Physical function in older people with rheumatoid arthritis and population controls: a cross-sectional study of self-reported and performance-based measures.Rheumatology international · 2026Article
- Multimorbidity as a predictor of mortality in companion dogs.GeroScience · 2026Article
- Association between multimorbidity patterns and activities of daily living function among older adults in China: a longitudinal population-based cohort study.BMC geriatrics · 2025Article
- Advancing healthcare allocation and prevention of disability: the role of disease-based predictive model for disability in aging adults.BMC geriatrics · 2025Article
- Association of multimorbidity trajectories from early adulthood through middle age with middle-age physical function.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Associations of Pain Characteristics With Physical Capacity Trajectories Among Older Adults in the United States.The Clinical journal of pain · 2025Article
- Multimorbidity clusters: translating research evidence into actionable interventions.European geriatric medicine · 2025Article
- Effects of Unequal Treatment, Verbal Harassment, and Physical Violence on Subjective Cognitive Health Among Middle-Aged and Older LGBTQ Adults: Variation by Type and Basis of Victimization.Annals of LGBTQ public and population health · 2025Article
- The Epidemiology of the Long-Term Care Needs and Unmet Needs of Older Veterans in the United States.Journal of clinical medicine · 2025Article
- Contribution of chronic conditions to mortality: Differences by race and ethnicity.Aging and health research · 2025Article
- Informal Care Receiving Among Older Adults: The Role of Multimorbidity and Intersectional Social Position.The Gerontologist · 2025Article
- Nurse Practitioner Care Environments and Provider Shortages Among Patients With Multiple Chronic Conditions.Research in nursing & health · 2025Article
- Association of possible Sarcopenia, Sarcopenia and sarcopenic obesity with multimorbidity among middle-aged and older adults: findings from the China health and retirement longitudinal study.Archives of public health = Archives belges de sante publique · 2025Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMultimorbidity (multiple co-occurring chronic diseases) is associated with greater likelihood of disability and mortality, above and beyond the risk attributable to individual diseases. This study identifies prevalent multimorbidity patterns and evaluates their association with disability among U.S. older adults.
methodsProspective cohort study using longitudinal Health and Retirement Study data (2010-2012). We included 8,782 participants aged 65 years and older and used negative binomial models to examine prospective disability, measured by the combined activities of daily living-instrumental activities of daily living index. Multimorbidity was defined as the co-occurring combination of at least two of the following chronic diseases: hypertension, cardiovascular disease, lung disease, diabetes, cancer, arthritis, stroke, cognitive impairment, or high depressive symptoms (CES-D score ≥ 4).
resultsWe found 291 unique disease combinations with 1 to 1,167 older adults per disease combination. The three most prevalent combinations were: (a) hypertension and arthritis (n = 1,167); (b) hypertension, arthritis, and cardiovascular disease (n = 510); and (c) hypertension, arthritis, and diabetes (n = 430). Only one of the prevalent combinations included depressive symptoms (in combination with arthritis, hypertension; n = 129). This group showed the highest level of activities of daily living-instrumental activities of daily living disability compared to healthy participants or participants with a single disease (either included in the combination or different from diseases in the combination) even after adjusting for age, gender, education, race/ethnicity, and body mass index.
conclusionsClinicians stand to gain from a better understanding of which disease combinations are more and less disabling among older adults. Understanding how multimorbidity combinations relate to functional status is an important step towards reducing disability and sustaining independent living among older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.