ArticleBMC cancer2016
The effect of visceral obesity on clinicopathological features in patients with endometrial cancer: a retrospective analysis of 200 Chinese patients.
Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Mechanism of PTPN18 for regulating the migration and invasion of endometrial cancer cells via the MYC/PI3K/AKT pathway.Histology and histopathology · 2025Article
- Correlation between abdominal visceral fat and the risk of endometrial cancer in patients with polycystic ovary syndrome.African health sciences · 2024Article
- The impact of adipose tissue distribution on endometrial cancer: a systematic review.Frontiers in oncology · 2023Review
- High visceral fat to subcutaneous fat ratios portend a poor prognosis in patients with advanced endometrial cancer.Gynecologic oncology · 2022Article
- Visceral-to-subcutaneous fat ratio is a possible prognostic factor for type 1 endometrial cancer.International journal of clinical oncology · 2022Article
- Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study.Clinical Medicine Insights. Oncology · 2022Article
- Metabolic Activity of Visceral Adipose Tissue Is Associated with Metastatic Status of Lymph Nodes in Endometrial Cancer: AInternational journal of environmental research and public health · 2021Article
- KIF2C Is a Novel Prognostic Biomarker and Correlated with Immune Infiltration in Endometrial Cancer.Stem cells international · 2021Article
- Clear cell renal cell carcinoma: the value of sex-specific abdominal visceral fat measured on CT for prediction of Fuhrman nuclear grade.European radiology · 2020Article
- Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer.Oncogene · 2019Article
- Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study.BMC cancer · 2019Article
- Implication of visceral obesity in patients with esophageal squamous cell carcinoma.Langenbeck's archives of surgery · 2018Article
- High visceral fat percentage is associated with poor outcome in endometrial cancer.Oncotarget · 2017Article
- Body Mass Index Is Positively Associated with Endometrial Cancer in Chinese Women, Especially Prior to Menopause.Journal of Cancer · 2016Article
- Influence of Obesity on the Course of Malignant Neoplastic Disease in Patients After Pulmonary Metastasectomy.In vivo (Athens, Greece)Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the effect of visceral adiposity on clinical and pathological characteristics in patients with endometrial cancer.
methodsA retrospective review of medical documentation was performed in surgically treated endometrial cancer patients from January to November 2015 in our institution. The visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured at the level of umbilicus on single-slice computerized tomography. Visceral adiposity (VAT%) was calculated as VAT/(VAT + SAT).
resultsA total of 200 cases were included in the study. Median age at diagnosis was 54 years old. Most patients presented with early-stage tumor (86.0% for I + II) and endometrioid histology (90.5%). Positive lymph node occurred in 11.0% (22/200) of the patients with the median number of retrieved nodes as 25 (range, 4-56). The entire population had a median body mass index (BMI) of 24.7 kg/m(2) and median VAT% of 31.89%. BMI correlated with total adipose tissue (correlation coefficient = 0.667, P < 0.001), but not with VAT% (P = 0.495). Viscerally obese patients tended to be old and post-menopausal (P < 0.001; P = 0.003). Nodal metastasis and extrauterine disease were more commonly reported in patients with high VAT% (6.0% vs. 16.0%, P = 0.024; 9.0% vs. 19.0%, P = 0.042, respectively). Univariate and multivariate logistic regressions were performed to discern the contribution of variable factors on the lymph node metastasis. Grade (HR = 15.41, 95% CI = 1.60-148.76; P = 0.018), lympho-vascular invasion (HR = 449.61, 95% CI = 31.27-6463.93; P < 0.001) and high VAT% (HR = 6.37, 95% CI = 1.42-28.69; P = 0.016) retained statistical significance for predicting lymph node metastasis.
conclusionsViscerally obese patients were more likely to be old and have positive lymph node as well as extrauterine disease. Grade, lympho-vascular invasion presence and visceral adiposity were predictors of nodal disease.
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