Evidence map›Paper›PMID 26968165›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Vitamin D supplementation in breastfed infants from Montréal, Canada: 25-hydroxyvitamin D and bone health effects from a follow-up study at 3 years of age.

S Gallo, T Hazell, C A Vanstone, S Agellon, G Jones, M L'Abbé, C Rodd, H A Weiler

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023
    Review
  7. Article
  8. Article
  9. Vitamin D prophylaxis in infancy.BMC pediatrics · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Update of the tolerable upper intake level for vitamin D for infants.EFSA journal. European Food Safety Authority · 2018
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

S GalloDepartment of Nutrition and Food Studies, George Mason University, Fairfax, VA, 22030, USA.
T HazellDepartment of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, Canada.
C A VanstoneSchool of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Québec, H9X 3V9, Canada.
S AgellonSchool of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Québec, H9X 3V9, Canada.
G JonesDepartment of Biomedical and Molecular Sciences in the School of Medicine, Queen's University, Kingston, ON, Canada.
M L'AbbéDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
C RoddWinnipeg Children's Hospital, University of Manitoba, Winnipeg, MB, Canada.
H A WeilerSchool of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Québec, H9X 3V9, Canada. hope.weiler@mcgill.ca.
McGill University · CAChildren's Hospital of Winnipeg · CAGeorge Mason University · USQueen's University · CAUniversity of Toronto · CAWilfrid Laurier University · CA

Funding

CIHR
6 · The paper itself

Abstract

unlabelledWhether infant vitamin D supplementation may have long-term bone benefits is unclear. In this study, breastfed infants who received vitamin dosages greater than 400 IU/day did not have higher bone mineralization at 3 years. This study provides important data to inform pediatric public health recommendations for vitamin D.

introductionNorth American health agencies recommend breastfed infants should be supplemented with 400 IU of vitamin D/day to support bone health. Few studies examined the long-term benefits of early life vitamin D supplementation on bone mineralization. The objective of this study was to determine if a dose-response relationship exists between infant vitamin D supplementation, vitamin D status, and bone outcomes at 3 years of age.

methodsThis was a double-blind randomized trial of 132, 1-month-old healthy, breastfed infants from Montréal, Canada, between 2007 and 2010. In this longitudinal analysis, 87 infants (66 %) returned for follow-up at 3 years of age, between 2010 and 2013. At 1 month of age, participants were randomly assigned to receive oral cholecalciferol (vitamin D3) supplements of 400, 800, 1200, or 1600 IU/day until 12 months of age. Lumbar spine vertebrae 1-4 (LS) bone mineral density (BMD), LS and whole body bone mineral content (BMC), and mineral accretion were measured by dual-energy x-ray absorptiometry at 3 years.

resultsAt follow-up, the treatment groups were similar in terms of diet, sun exposure, and demographics. There were no significant differences among the groups in LS or whole body BMC, BMD, or accretion. Although, 25(OH)D concentrations were not different among the groups, higher doses (1200 and 1600 IU/day) achieved higher 25(OH)D area under the curve from 1 to 36 months vs. 400 IU/day.

conclusionsThis is the first longitudinal follow-up of an infant vitamin D dose-response study which examines bone mineralization at 3 years of age. Dosages higher than 400 IU/day do not appear to provide additional benefits to the bone at follow-up. Larger studies with more ethnically diverse groups are needed to confirm these results.

Indexed as

Bone DensityDietary SupplementsBreast FeedingCanadaChild, PreschoolCholecalciferolDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantMaleVitamin D25-hydroxyvitamin DCholecalciferolVitamin D25-hydroxyvitamin DBone mineralBone mineral accretionDual-energy x-ray absorptiometryInfantsPediatricsSupplementationVitamin D

Identifiers

PMID26968165
OpenAlexW2295627055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.