ArticleJournal of the American Chemical Society2016
Ratiometric Array of Conjugated Polymers-Fluorescent Protein Provides a Robust Mammalian Cell Sensor.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- A fingerprint-based polymeric sensing platform for comprehensive quality assessment of complex culture media in cell manufacturing.Chemical science · 2026Article
- A Sensitive Multichannel Fluorescent Polymer Sensor Array for the Detection of Protein Fluctuations in Serum.Sensors (Basel, Switzerland) · 2026Article
- Research Advances in Conjugated Polymer-Based Optical Sensor Arrays for Early Diagnosis of Clinical Diseases.Polymers · 2026Review
- Advances and Innovations in Conjugated Polymer Fluorescent Sensors for Environmental and Biological Detection.Biosensors · 2025Review
- A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria.Biomacromolecules · 2024Article
- Chemical tongues as multipurpose bioanalytical tools for the characterization of complex biological samples.Biophysics and physicobiology · 2024Review
- Molecules that Generate Fingerprints: A New Class of Fluorescent Sensors for Chemical Biology, Medical Diagnosis, and Cryptography.Accounts of chemical research · 2023Review
- A Multichannel Fluorescent Array Sensor for Discrimination of Different Types of Drug-Induced Kidney Injury.Sensors (Basel, Switzerland) · 2023Article
- Kaleidoscopic fluorescent arrays for machine-learning-based point-of-care chemical sensing.Sensors and actuators. B, Chemical · 2021Article
- Pattern-recognition-based Sensor Arrays for Cell Characterization: From Materials and Data Analyses to Biomedical Applications.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Review
- Luminescent europium(III)-organic framework for visual and on-site detection of hydrogen peroxide via a tablet computer.Mikrochimica acta · 2020Article
- Micellization-induced amplified fluorescence response for highly sensitive detection of heparin in serum.Scientific reports · 2020Article
- Light-Emitting Multifunctional Maleic Acid-ACS omega · 2020Article
- Molecular recognition with soft biomaterials.Soft matter · 2020Article
- Array-Based Discriminative Optical Biosensors for Identifying Multiple Proteins in Aqueous Solution and Biofluids.Frontiers in chemistry · 2020Review
- Fluorescence spectral shape analysis for nucleotide identification.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Array-based "Chemical Nose" Sensing in Diagnostics and Drug Discovery.Angewandte Chemie (International ed. in English) · 2019Review
- Protein⁻Polyelectrolyte Interaction: Thermodynamic Analysis Based on the Titration MethodPolymers · 2019Review
- Fluorescent Sensor Arrays Can Predict and Quantify the Composition of Multicomponent Bacterial Samples.Frontiers in chemistry · 2019Article
- Array-Based Protein Sensing Using an Aggregation-Induced Emission (AIE) Light-Up Probe.ACS omega · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Supramolecular complexes of a family of positively charged conjugated polymers (CPs) and green fluorescent protein (GFP) create a fluorescence resonance energy transfer (FRET)-based ratiometric biosensor array. Selective multivalent interactions of the CPs with mammalian cell surfaces caused differential change in FRET signals, providing a fingerprint signature for each cell type. The resulting fluorescence signatures allowed the identification of 16 different cell types and discrimination between healthy, cancerous, and metastatic cells, with the same genetic background. While the CP-GFP sensor array completely differentiated between the cell types, only partial classification was achieved for the CPs alone, validating the effectiveness of the ratiometric sensor. The utility of the biosensor was further demonstrated in the detection of blinded unknown samples, where 121 of 128 samples were correctly identified. Notably, this selectivity-based sensor stratified diverse cell types in minutes, using only 2000 cells, without requiring specific biomarkers or cell labeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.