Evidence map›Paper›PMID 26967720›Full record

ReviewCurrent opinion in oncology2016

Prostate-specific membrane antigen positron emission tomography in prostate cancer: a step toward personalized medicine.

Kirsten Bouchelouche, Peter L Choyke

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Diagnostic value of two-time point [Scientific reports · 2023
    Article
  3. Salvage lymph node dissection for prostate-specific membrane antigen (PSMA) positron emission tomography (PET)-identified oligometastatic disease.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021
    Article
  4. Review
  5. Optimized Application ofFrontiers in medicine · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. PSMA PET and Radionuclide Therapy in Prostate Cancer.Seminars in nuclear medicine · 2016
    Review
  19. Unusual presentation of castrate-resistant prostate cancer with urethral and inguinal nodal metastasis.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kirsten BoucheloucheaDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark bMolecular Imaging Program, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, Maryland, USA.
Peter L Choyke
Aarhus University Hospital · DKNational Cancer Institute · US

Funding

Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
Prostate Cancer ImagingZ01BC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2005 to 2008
$2.1M
Intramural NIH HHS Z01 BC010655
6 · The paper itself

Abstract

purpose of reviewIncreasing attention is being given to personalized medicine in oncology, where therapies are tailored to the particular characteristics of the individual cancer patient. In recent years, there has been greater focus on prostate-specific membrane antigen (PSMA) in prostate cancer (PCa) as a target for imaging and therapy with radionuclides. This review highlights the recent advancements in PSMA positron emission tomography (PET) in PCa during the past year. RECENT

findingsSeveral reports on PSMA PET/computed tomography (CT) in PCa patients are demonstrating promising results, especially for detection of biochemical recurrence. F-PSMA PET/CT may be superior to Ga-PSMA PET/CT. The detection rate of PSMA PET is influenced by prostate-specific antigen level. PSMA PET/CT may have a higher detection rate than choline PET/CT. Only a few reports have been published on PSMA PET/magnetic resonance imaging (MRI), and this modality remains to be elucidated further. SUMMARY: Molecular imaging with PSMA PET is paving the way for personalized medicine in PCa. However, large prospective clinical studies are needed to further evaluate the role of PSMA PET/CT and PET/MRI in the clinical workflow of PCa. PSMA is an excellent target for imaging and therapy with radionuclides, and the 'image and treat' strategy has the potential to become a milestone in the management of PCa patients.

Indexed as

HumansKallikreinsMalePositron-Emission TomographyPrecision MedicineProstate-Specific AntigenProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantKallikreinsKLK3 protein, humanProstate-Specific Antigen

Identifiers

PMID26967720
PMCPMC5515231
OpenAlexW2321373517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.