Demyelination and neurodegeneration in multiple sclerosis: The role of hypoxia.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity.Multiple sclerosis and related disorders · 2019
   Trial
2. Hypoxia in multiple sclerosis.Redox biology · 2025
   Review
3. Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination.Journal of neuroinflammation · 2025
   Article
4. New Insights into the Mechanism by Which the Pituitary Gland Copes with Hypoxia Stress Based on a Transcriptomic Analysis ofGenes · 2024
   Article
5. Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event.Brain : a journal of neurology · 2021
   Article
6. Metabolic Regulation of Glial Phenotypes: Implications in Neuron-Glia Interactions and Neurological Disorders.Frontiers in cellular neuroscience · 2020
   Review
7. Oligodendrocyte Bioenergetics in Health and Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019
   Review
8. Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.Clinical epigenetics · 2019
   Article
9. Advances in brain imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019
   Review
10. EGFL7 reduces CNS inflammation in mouse.Nature communications · 2018
    Article
11. Nogo-A Antibodies for Progressive Multiple Sclerosis.CNS drugs · 2017
    Review
12. Creatine Enhances Mitochondrial-Mediated Oligodendrocyte Survival After Demyelinating Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
13. Sleep-Disordered Breathing in People with Multiple Sclerosis: Prevalence, Pathophysiological Mechanisms, and Disease Consequences.Frontiers in neurology · 2017
    Review

Corrections and comments

• Comment on
  Cause and prevention of demyelination in a model multiple sclerosis lesion.2016

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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