ArticleMicrobiology (Reading, England)2016
Enterococcus faecalis Ebp pili are important for cell-cell aggregation and intraspecies gene transfer.
Article in Microbiology (Reading, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Integrated One-Health analysis of antimicrobial resistance, biofilm formation, and genetic relatedness of Enterococcus spp. at the human-food interface.Scientific reports · 2026Article
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- Bacterial adhesion strategies and countermeasures in urinary tract infection.Nature microbiology · 2025Review
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- Colonization of vancomycin-resistantFEMS microbes · 2024Article
- An Overview of the Factors Involved in Biofilm Production by theInternational journal of molecular sciences · 2023Review
- Antibacterial and antibiofilm activities of thyme oil against foodborne multiple antibiotics-resistant Enterococcus faecalis.Poultry science · 2020Article
- Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies.Nature reviews. Microbiology · 2020Review
- Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity AmongFrontiers in microbiology · 2020Article
- Biofilm-associated infection by enterococci.Nature reviews. Microbiology · 2019Review
- Planktonic Interference and Biofilm Alliance between Aggregation Substance and Endocarditis- and Biofilm-Associated Pili in Enterococcus faecalis.Journal of bacteriology · 2018Article
- Global Emergence and Dissemination of Enterococci as Nosocomial Pathogens: Attack of the Clones?Frontiers in microbiology · 2016Review
- Exploiting biofilm phenotypes for functional characterization of hypothetical genes inNPJ biofilms and microbiomesArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Enterococcus faecalis is an opportunistic pathogen that ranks among the leading causes of biofilm-associated infections. We previously demonstrated that the endocarditis- and biofilm-associated pili (Ebp) of E. faecalis play a major role in biofilm formation, adherence to abiotic surfaces and experimental infections. In this study, derivatives of E. faecalis strain OG1 were engineered to further characterize functions of Ebp pili. Loss of pili resulted in a 36-fold decrease in the number of closely associated cells when OG1RFΔebpABC was mixed with OG1SSpΔebpABC, compared with mixing the Ebp+ parental strains. In addition, using the Ebp+ parental strains as donor and recipient, we found a statistically significant increase (280-360 %, P < 0.05) in the frequency of plasmid transfer versus using Ebp- mutants in the conjugation experiments. These results demonstrate a previously unrecognized role of Ebp pili, namely, as important contributors to microscale cell aggregation and horizontal spread of genetic material.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.