ArticleEnvironmental health perspectives2016
Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men: The Normative Aging Study.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Associations of exposure to PMBMC public health · 2025Pooled it
- A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter.Environment international · 2019Pooled it
- Heterogeneous and nonlinear associations between depressive symptoms and functional disability in older Chinese adults.BMC psychology · 2026Article
- Performance of quantile regression methods with discrete outcomes: A simulation study with applications to environmental epidemiology.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Cardiac electrophysiological responses to traffic pollution in adults with or without chronic cardiopulmonary diseases.Environment international · 2025Article
- Blood Pressure Variability and Low-Grade Inflammation in Pediatric Patients with Primary Hypertension.Journal of clinical medicine · 2025Article
- Effects of intermediate and long-term exposure to ambient air pollution and temperature on hospital admissions with second cardiovascular events among medicare beneficiaries.Environment international · 2025Article
- Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study.Eco-Environment & Health · 2025Article
- The Association between Exposure to Fine Particulate Matter and MRI-Assessed Locus Coeruleus Integrity in the Vietnam Era Twin Study of Aging (VETSA).Environmental health perspectives · 2024Article
- Similarities and Differences in the Longitudinal Trajectories of Depressive Symptoms from Mid-Adolescence to Young Adulthood: the Intersectionality of Gender, Race/Ethnicity, and Levels of Depressive Symptoms.Journal of racial and ethnic health disparities · 2024Article
- Longitudinal associations between ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024Article
- The association between long-term exposure to ambient PMBMC cardiovascular disorders · 2024Article
- Relationship between exposure to fine particulate matter and cardiovascular risk factors and the modifying effect of socioeconomic status: a cross-sectional study in Beijing, China.Frontiers in public health · 2024Article
- Review
- Identifying the Relationship between PMToxics · 2023Article
- Semiparametric distributed lag quantile regression for modeling time-dependent exposure mixtures.Biometrics · 2023Article
- Effects of ambient particulate exposure on blood lipid levels in hypertension inpatients.Frontiers in public health · 2023Article
- Association of Short-Term Exposure to PMToxics · 2022Article
- Cardiovascular Health Peaks and Meteorological Conditions: A Quantile Regression Approach.International journal of environmental research and public health · 2021Article
- Interpreting a standardized and normalized measure of neighborhood socioeconomic status for a better understanding of health differences.Archives of public health = Archives belges de sante publique · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPrevious studies have observed associations between air pollution and heart disease. Susceptibility to air pollution effects has been examined mostly with a test of effect modification, but little evidence is available whether air pollution distorts cardiovascular risk factor distribution.
objectivesThis paper aims to examine distributional and heterogeneous effects of air pollution on known cardiovascular biomarkers.
methodsA total of 1,112 men from the Normative Aging Study and residents of the greater Boston, Massachusetts, area with mean age of 69 years at baseline were included in this study during the period 1995-2013. We used quantile regression and random slope models to investigate distributional effects and heterogeneity in the traffic-related responses on blood pressure, heart rate variability, repolarization, lipids, and inflammation. We considered 28-day averaged exposure to particle number, PM2.5 black carbon, and PM2.5 mass concentrations (measured at a single monitor near the site of the study visits).
resultsWe observed some evidence suggesting distributional effects of traffic-related pollutants on systolic blood pressure, heart rate variability, corrected QT interval, low density lipoprotein (LDL) cholesterol, triglyceride, and intercellular adhesion molecule-1 (ICAM-1). For example, among participants with LDL cholesterol below 80 mg/dL, an interquartile range increase in PM2.5 black carbon exposure was associated with a 7-mg/dL (95% CI: 5, 10) increase in LDL cholesterol, while among subjects with LDL cholesterol levels close to 160 mg/dL, the same exposure was related to a 16-mg/dL (95% CI: 13, 20) increase in LDL cholesterol. We observed similar heterogeneous associations across low versus high percentiles of the LDL distribution for PM2.5 mass and particle number.
conclusionsThese results suggest that air pollution distorts the distribution of cardiovascular risk factors, and that, for several outcomes, effects may be greatest among individuals who are already at high risk. CITATION: Bind MA, Peters A, Koutrakis P, Coull B, Vokonas P, Schwartz J. 2016. Quantile regression analysis of the distributional effects of air pollution on blood pressure, heart rate variability, blood lipids, and biomarkers of inflammation in elderly American men: the Normative Aging Study. Environ Health Perspect 124:1189-1198; http://dx.doi.org/10.1289/ehp.1510044.
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