Evidence map›Paper›PMID 26967517›Full record

ArticlePloS one2016

Opt-Out Panel Testing for HIV, Hepatitis B and Hepatitis C in an Urban Emergency Department: A Pilot Study.

Sarah O'Connell, Darren Lillis, Aoife Cotter, Siobhan O'Dea, Helen Tuite, Catherine Fleming, Brendan Crowley, Ian Fitzgerald, Linda Dalby, Helen Barry and 4 more

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Article
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  9. Article
  10. Testing for human immunodeficiency virus.Australian prescriber · 2025
    Review
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  19. Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarah O'ConnellDepartment of Genito-Urinary Medicine and Infectious Disease, St James's Hospital, Dublin, Ireland.
Darren LillisEmergency Medicine Department, St James's Hospital, Dublin, Ireland.
Aoife CotterDepartment of Genito-Urinary Medicine and Infectious Disease, St James's Hospital, Dublin, Ireland.
Siobhan O'DeaDepartment of Genito-Urinary Medicine and Infectious Disease, St James's Hospital, Dublin, Ireland.
Helen TuiteInfectious Diseases Department, Galway University Hospital, Dublin, Ireland.
Catherine FlemingInfectious Diseases Department, Galway University Hospital, Dublin, Ireland.
Brendan CrowleyMicrobiology Department, St James's Hospital, Dublin, Ireland.
Ian FitzgeraldMicrobiology Department, St James's Hospital, Dublin, Ireland.
Linda DalbyMicrobiology Department, St James's Hospital, Dublin, Ireland.
Helen BarryMicrobiology Department, St James's Hospital, Dublin, Ireland.
Darragh ShieldsEmergency Medicine Department, St James's Hospital, Dublin, Ireland.
Suzanne NorrisHepatology Department, St James's Hospital, Dublin, Ireland.
Patrick K PlunkettEmergency Medicine Department, St James's Hospital, Dublin, Ireland.
Colm BerginDepartment of Genito-Urinary Medicine and Infectious Disease, St James's Hospital, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesStudies suggest 2 per 1000 people in Dublin are living with HIV, the level above which universal screening is advised. We aimed to assess the feasibility and acceptability of a universal opt-out HIV, Hepatitis B and Hepatitis C testing programme for Emergency Department patients and to describe the incidence and prevalence of blood-borne viruses in this population.

methodsAn opt-out ED blood borne virus screening programme was piloted from March 2014 to January 2015. Patients undergoing blood sampling during routine clinical care were offered HIV 1&2 antibody/antigen assay, HBV surface antigen and HCV antibody tests. Linkage to care where necessary was co-ordinated by the study team. New diagnosis and prevalence rates were defined as the new cases per 1000 tested and number of positive tests per 1000 tested respectively.

resultsOver 45 weeks of testing, of 10,000 patient visits, 8,839 individual patient samples were available for analysis following removal of duplicates. A sustained target uptake of >50% was obtained after week 3. 97(1.09%), 44(0.49%) and 447(5.05%) HIV, Hepatitis B and Hepatitis C tests were positive respectively. Of these, 7(0.08%), 20(0.22%) and 58(0.66%) were new diagnoses of HIV, Hepatitis B and Hepatitis C respectively. The new diagnosis rate for HIV, Hepatitis B and Hepatitis C was 0.8, 2.26 and 6.5 per 1000 and study prevalence for HIV, Hepatitis B and Hepatitis C was 11.0, 5.0 and 50.5 per 1000 respectively.

conclusionsOpt-out blood borne viral screening was feasible and acceptable in an inner-city ED. Blood borne viral infections were prevalent in this population and newly diagnosed cases were diagnosed and linked to care. These results suggest widespread blood borne viral testing in differing clinical locations with differing population demographic risks may be warranted.

Indexed as

AdultCross-Sectional StudiesEmergency Service, HospitalFemaleHepatitis BHepatitis B Surface AntigensHepatitis CHepatitis C AntibodiesHIV AntigensHIV InfectionsHospitals, UrbanHumansIrelandMaleMass ScreeningMiddle AgedHepatitis B Surface AntigensHepatitis C AntibodiesHIV Antigens

Identifiers

PMID26967517
PMCPMC4788349

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.