Evidence map›Paper›PMID 26967477›Full record

ArticleThe Journal of investigative dermatology2016

Palmoplantar Keratoderma in Slurp2-Deficient Mice.

Christopher M Allan, Shiri Procaccia, Deanna Tran, Yiping Tu, Richard H Barnes, Mikael Larsson, Bernard B Allan, Lorraine C Young, Cynthia Hong, Peter Tontonoz and 3 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Article
  5. Evolution and Medical Significance of LU Domain-Containing Proteins.International journal of molecular sciences · 2019
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Christopher M AllanDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Shiri ProcacciaDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Deanna TranDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Yiping TuDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Richard H BarnesDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Mikael LarssonDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Bernard B AllanDepartment of Molecular Biology, Genentech, South San Francisco, California, USA.
Lorraine C YoungDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Cynthia HongDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Howard Hughes Medical Institute, University of California, Los Angeles, California, USA.
Peter TontonozDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Howard Hughes Medical Institute, University of California, Los Angeles, California, USA.
Loren G FongDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA. Electronic address: lfong@mednet.ucla.edu.
Stephen G YoungDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA. Electronic address: sgyoung@mednet.ucla.edu.
Anne P BeigneuxDepartment of Medicine, Divisions of Cardiology and Dermatology, David Geffen School of Medicine, University of California, Los Angeles, California, USA. Electronic address: abeigneux@mednet.ucla.edu.
University of California, Los Angeles · USHoward Hughes Medical Institute · US

Funding

The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
Howard Hughes Medical InstituteNHLBI NIH HHS P01 HL090553
6 · The paper itself

Abstract

SLURP1, a member of the lymphocyte antigen 6 protein family, is secreted by suprabasal keratinocytes. Mutations in SLURP1 cause a palmoplantar keratoderma (PPK) known as mal de Meleda. SLURP2, another secreted lymphocyte antigen 6 protein, is encoded by a gene located ?20 kb downstream from SLURP1. SLURP2 is produced by suprabasal keratinocytes. To investigate the importance of SLURP2, we first examined Slurp2 knockout mice in which exon 2-3 sequences had been replaced with lacZ and neo cassettes. Slurp2(-/-) mice exhibited hyperkeratosis on the volar surface of the paws (i.e., palmoplantar keratoderma), increased keratinocyte proliferation, and an accumulation of lipid droplets in the stratum corneum. They also exhibited reduced body weight and hind limb clasping. These phenotypes are similar to those of Slurp1(-/-) mice. To solidify a link between Slurp2 deficiency and palmoplantar keratoderma and to be confident that the disease phenotypes in Slurp2(-/-) mice were not secondary to the effects of the lacZ and neo cassettes on Slurp1 expression, we created a new line of Slurp2 knockout mice (Slurp2X(-/-)) in which Slurp2 was inactivated with a simple nonsense mutation. Slurp2X(-/-) mice exhibited the same disease phenotypes. Thus, Slurp2 deficiency and Slurp1 deficiencies cause the same disease phenotypes.

Indexed as

Codon, NonsenseGene Expression RegulationAdaptor Proteins, Signal TransducingAnimalsAntigens, LyCells, CulturedDisease Models, AnimalGPI-Linked ProteinsImmunohistochemistryKeratinocytesKeratoderma, PalmoplantarMiceMice, KnockoutPhenotypeRandom AllocationReal-Time Polymerase Chain ReactionAdaptor Proteins, Signal TransducingAntigens, LyCodon, NonsenseGPI-Linked ProteinsLYNX1 protein, humanSLURP-1 protein, mouseUrokinase-Type Plasminogen Activator

Identifiers

PMID26967477
PMCPMC4789766
OpenAlexW2250930869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.