ArticleJournal of visualized experiments : JoVE2016
Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Pain-related function, muscle stiffness, and muscle activation in adults with patellofemoral pain.BMC musculoskeletal disorders · 2026Article
- A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations.The Journal of general physiology · 2026Review
- Insights into human muscle biology from human primary skeletal muscle cell culture.Journal of muscle research and cell motility · 2025Review
- Safety of Anesthesia With Dexmedetomidine for Muscle and Nerve Biopsy - A Review of 100 Cases.Cureus · 2025Article
- Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.Nature aging · 2025Article
- DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults.Skeletal muscle · 2023Article
- A Coupled Mechanobiological Model of Muscle Regeneration In Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2021Article
- The Art of Muscle Biopsy in the New Genetic Era: A Narrative Review.Iranian journal of child neurology · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Percutaneous muscle biopsy using the Weil-Blakesley conchotome is well established in both clinical and research practice. It is a safe, effective and well tolerated technique. The Weil-Blakesley conchotome has a sharp biting tip with a 4 - 6 mm wide hollow. It is inserted through a 5 - 10 mm skin incision and can be maneuvered for controlled tissue penetration. The tip is opened and closed within the tissue and then rotated through 90 -180° to cut the muscle. The amount of muscle obtained following repeated sampling can vary from 20 mg to 290 mg which can be processed for both histology and molecular studies. The wound needs to be kept dry and vigorous physical activity kept to a minimum for approximately 72 hr although normal levels of activity can restart immediately following the procedure. This procedure is safe and effective when close attention is paid to the selection of subjects, full asepsis and post procedure care. Both right and left vastus lateralis are suitable for biopsy dependent on participant preference.
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Registered trials
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