Evidence map›Paper›PMID 26967302›Full record

ArticleSexually transmitted diseases2016

HIV Incidence Among Men Who Have Sex With Men After Diagnosis With Sexually Transmitted Infections.

David A Katz, Julia C Dombrowski, Teal R Bell, Roxanne P Kerani, Matthew R Golden

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  12. Acceptability of PC-1005 Gel Administered Rectally to HIV-1 Seronegative Adults at Three Different Volume Levels (MTN-037).AIDS education and prevention : official publication of the International Society for AIDS Education · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David A KatzFrom the Departments of *Medicine and †Epidemiology, University of Washington, Seattle, WA; ‡HIV/STD Program, Public Health-Seattle & King County, Seattle, WA; and §Infectious Disease Assessment Unit, Washington State Department of Health, Olympia, WA.
Julia C Dombrowski
Teal R Bell
Roxanne P Kerani
Matthew R Golden
National Institute on Drug Abuse · USNational Institutes of Health · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
PS12-1201 COMPREHENSIVE HIV PREVENTION PROJECT FOR HEALTH DEPTSU62PS003666 · PS · WASHINGTON STATE DEPARTMENT OF HEALTH · PI KERN, DAVID E · 2012 to 2016
$16.3M
IMPRVG STD PRGRMS THRU ASSMT, ASSRNCE, PLCY DEV & PREV STRATH25PS004364 · PS · WASHINGTON STATE DEPARTMENT OF HEALTH · PI KERN, DAVID E · 2014 to 2016
$5.3M
NCHHSTP CDC HHS H25 PS004364NCHHSTP CDC HHS PS12-1201NCHHSTP CDC HHS U62 PS003666NIAID NIH HHS P30 AI027757NIAID NIH HHS P30AI027757
6 · The paper itself

Abstract

backgroundMen who have sex with men (MSM) are at high risk for acquiring HIV infection after diagnosis with other sexually transmitted infections (STIs). Identifying the STIs associated with the greatest risk of subsequent HIV infection could help target prevention interventions, particularly preexposure prophylaxis (PrEP).

methodsUsing matched HIV and STI surveillance data from Washington State from January 1, 2007, to June 30, 2013, we calculated the incidence of new HIV diagnoses after different STI diagnoses among MSM. Men entered observation at the time of their first STI diagnosis during the study period and exited at HIV diagnosis or June 30, 2013. Cox proportional hazards regression was used to conduct a global comparison of rates.

resultsFrom January 1, 2007, to June 30, 2013, 6577 HIV-negative MSM were diagnosed as having 10,080 bacterial STIs at 8371 unique time points and followed for 17,419 person-years. Two hundred eighty (4.3%) men were subsequently diagnosed as having HIV infection for an overall incidence of 1.6 per 100 person-years (95% confidence interval, 1.4-1.8). The estimated incidence of HIV diagnoses among all MSM in the state was 0.4 per 100 person-years. Men who have sex with men were at the greatest risk for HIV diagnosis after being diagnosed as having rectal gonorrhea (HIV incidence, 4.1 per 100 person-years), followed by early syphilis (2.8), urethral gonorrhea (1.6), rectal chlamydial infection (1.6), pharyngeal gonorrhea (1.1), late syphilis (1.0), and urethral chlamydial infection (0.6; P < 0.0001 overall).

conclusionsMen who have sex with men diagnosed as having rectal gonorrhea and early syphilis were at the greatest risk for being diagnosed as having HIV infection after STI diagnosis. These men should be prioritized for more intensive prevention interventions, including PrEP.

Indexed as

AdolescentAdultChlamydia InfectionsGonorrheaHIV InfectionsHomosexuality, MaleHumansIncidenceMaleMiddle AgedPre-Exposure ProphylaxisRiskSexually Transmitted DiseasesSyphilisWashingtonYoung Adult

Identifiers

PMID26967302
PMCPMC4789769
OpenAlexW2343046980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.