Evidence map›Paper›PMID 26967290›Full record

ReviewCell2016

Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.

Gerard Karsenty, Eric N Olson

Abstract readReview
In one paragraph

Review in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed.

  1. Trial
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  13. Special Issue "Hormone Signaling in Human Health and Diseases".International journal of molecular sciences · 2026
    Article
  14. Bone as an endocrine regulator of lipid and energy metabolism.Reviews in endocrine & metabolic disorders · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gerard KarsentyDepartment of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: gk2172@cumc.columbia.edu.
Eric N OlsonDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Funding

Transcriptomic CoreP01AG032959 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gerard Karsenty · 2010 to 2026
$39.7M
Microenvironmental control of progenitors in organ dysfunction and repairU01HL100401 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N, SCHNEIDER, JAY W · 2009 to 2015
$8.3M
Heart Repair through Reprogramming of Cardiac Cell FateR01HL077439 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2004 to 2015
$6.2M
MicroRNA Control of Cardiac Gene Expression, Function and DiseaseR01HL093039 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2009 to 2013
$2.8M
Deciphering a Regulatory Circuit for Myocardial Metabolism and Energy HomeostasisR01HL111665 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2012 to 2015
$2.4M
Metabolic Control by Myogenic MicroRNAs, Mediator and MyokinesR01DK099653 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2013 to 2016
$1.9M
Regulation of Glucose Uptake in Osteoblasts by Runx2R01DK104727 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KARSENTY, GERARD · 2015 to 2019
$1.8M
Characterization of a receptor mediating adiponectin functions on boneR56AG049681 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KARSENTY, GERARD · 2015 to 2015
$440k
NHLBI NIH HHS HL-077439NHLBI NIH HHS HL-093039NHLBI NIH HHS HL-111665NHLBI NIH HHS R01 HL077439NHLBI NIH HHS R01 HL093039NHLBI NIH HHS R01 HL111665NHLBI NIH HHS U01 HL100401NHLBI NIH HHS U01-HL-100401NIA NIH HHS P01 AG032959NIA NIH HHS R56 AG049681NIDDK NIH HHS DK-099653NIDDK NIH HHS R01 DK099653NIDDK NIH HHS R01 DK104727
6 · The paper itself

Abstract

Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.

Indexed as

AnimalsBone and BonesCytokinesEnergy MetabolismHumansMiceMuscle, SkeletalOsteocalcinPhosphatesCytokinesOsteocalcinPhosphates

Identifiers

PMID26967290
PMCPMC4797632

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.